ChemicalBook > CAS DataBase List > (+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

Product Name
(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran
CAS No.
197706-51-7
Chemical Name
(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran
Synonyms
Nebivolol Isomer-A;A-Isomer Nebivolol;Nebivolol Impurity 10;Nebivolol A Isomer (Nebivolol Imp-28);(S)-6-fluoro-2-((R)-oxiran-2-yl)chroman;(2S, 2’R)-6-Fluoro-2-(2’-oxiranyl)chromane;(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran;2H-1-Benzopyran, 6-fluoro-3,4-dihydro-2-[(2R)-2-oxiranyl]-, (2S)-
CBNumber
CB74748565
Molecular Formula
C11H11FO2
Formula Weight
194.2
MOL File
197706-51-7.mol
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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Property

Boiling point:
285.4℃ at 102kPa
Density 
1.38g/cm3 at 20℃
vapor pressure 
0.21-0.4Pa at 20-25℃
form 
Solid
LogP
2.5-3.2 at pH7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

TRC
Product number
F595090
Product name
(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
Packaging
100mg
Price
$1540
Updated
2021/12/16
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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Chemical Properties,Usage,Production

Uses

(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker.

(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Suppliers

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