Ponazuril

Product Name: Ponazuril
CAS No.: 69004-04-2
Chemical Name: Ponazuril
Synonyms: 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;Veterinary Ponazuril;Toltrazuril Sulfone Standard;Toltrazuril sulfone Ponazuril;Ponazuril ，Toltrazuril sulfone
CBNumber: CB01075339
Molecular Formula: C18H14F3N3O6S
Formula Weight: 457.38
MOL File: 69004-04-2.mol

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Ponazuril Property

Melting point:: 242°
Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 6.46±0.20(Predicted)
color: White to Off-White
InChIKey: VBUNOIXRZNJNAD-UHFFFAOYSA-N
CAS DataBase Reference: 69004-04-2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33816
Product name: Toltrazuril sulfone
Purity: VETRANAL
Packaging: 10mg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 250mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 100mg
Price: $169
Updated: 2024/03/01

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Ponazuril Chemical Properties,Usage,Production

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Ponazuril Preparation Products And Raw materials

Raw materials

Preparation Products

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Ponazuril Suppliers

Canada 1 China 115 Germany 2 India 2 Switzerland 1 United Kingdom 1 United States 18 Global 140

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 027-027-52344656 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 3000
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

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View Lastest Price from Ponazuril manufacturers

Hebei Duling International Trade Co. LTD

Product: Ponazuril 69004-04-2
Price: US $2.50/kg
Min. Order: 1kg
Purity: 99.6%
Supply Ability: 20tons
Release date: 2024-05-20

Sinoway Industrial co., ltd.

Product: Ponazuril ，Toltrazuril sulfone 69004-04-2
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2022-08-25

Anhui Yiao New Material Technology Co., Ltd

Product: Toltrazuril sulfone 69004-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 tons
Release date: 2023-11-02

69004-04-2, PonazurilRelated Search:

D-Nebivolol,hydrochloride(1:1) Nebivolol Impurity 2 HCl (SR,RS) (+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol Defluoro Nebivolol (Mixture of DiastereoMers) Didefluoro Nebivolol (Mixture of DiastereoMers) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran (-)-Nebivolol Nebivolol Impurity 28 HCl (SS,RS) Nebivolol Impurity 3 Nebivolol Impurity 13 HCl (SS,SS) (2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran Toltrazuril 4-(Trifluoromethylthio)phenol 1-Methyl-3-{3-methyl-4-[4-(trifluormethylsulfinyl)-phenoxy]-phenyl}-1,3,5-triazin-2,4,6(1H,3H,5H)-trion 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE Ponazuril 1-Methanesulfonyl-4-phenoxy-benzene 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE

Toltrazuril sulfone Ponazuril

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H

Ponazuril

ToltrazurilSulfone

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Ponazuril [inn]

Unii-jpw84as66u

1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

Toltrazuril Sulfone Standard

1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]phenoxy]phenyl]-

Ponazurilr

Ponazuril ，Toltrazuril sulfone

Veterinary Ponazuril

69004-04-2

9004-04-2

C18H14F3N3O6S

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals