Ponazuril
- Product Name
- Ponazuril
- CAS No.
- 69004-04-2
- Chemical Name
- Ponazuril
- Synonyms
- 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;Veterinary Ponazuril;Toltrazuril Sulfone Standard;Toltrazuril sulfone Ponazuril;Ponazuril ，Toltrazuril sulfone
- CBNumber
- CB01075339
- Molecular Formula
- C18H14F3N3O6S
- Formula Weight
- 457.38
- MOL File
- 69004-04-2.mol
Ponazuril Property
- Melting point:
- 242°
- Density
- 1.507±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 6.46±0.20(Predicted)
- color
- White to Off-White
- InChIKey
- VBUNOIXRZNJNAD-UHFFFAOYSA-N
- CAS DataBase Reference
- 69004-04-2
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 33816
- Product name
- Toltrazuril sulfone
- Purity
- VETRANAL
- Packaging
- 10mg
- Price
- $323
- Updated
- 2024/03/01
- Product number
- 29655
- Product name
- Toltrazuril sulfone
- Packaging
- 50mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 29655
- Product name
- Toltrazuril sulfone
- Packaging
- 250mg
- Price
- $343
- Updated
- 2024/03/01
- Product number
- 29655
- Product name
- Toltrazuril sulfone
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29655
- Product name
- Toltrazuril sulfone
- Packaging
- 100mg
- Price
- $169
- Updated
- 2024/03/01
Ponazuril Chemical Properties,Usage,Production
Description
Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.
Uses
Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).
Veterinary Drugs and Treatments
Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis
(EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum
and Toxoplasma infections in dogs or cats.
Ponazuril Preparation Products And Raw materials
Raw materials
Preparation Products
Ponazuril Suppliers
View Lastest Price from Ponazuril manufacturers
- Product
- Ponazuril ，Toltrazuril sulfone 69004-04-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 99% up, High Density
- Supply Ability
- 20 tons
- Release date
- 2022-08-25
- Product
- Ponazuril 69004-04-2
- Price
- US $10.00-8.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06
- Product
- Toltrazuril sulfone 69004-04-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1 tons
- Release date
- 2023-11-02