ChemicalBook > CAS DataBase List > Ponazuril

Ponazuril

Product Name
Ponazuril
CAS No.
69004-04-2
Chemical Name
Ponazuril
Synonyms
1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;Veterinary Ponazuril;Toltrazuril Sulfone Standard;Toltrazuril sulfone Ponazuril;Ponazuril ，Toltrazuril sulfone
CBNumber
CB01075339
Molecular Formula
C18H14F3N3O6S
Formula Weight
457.38
MOL File
69004-04-2.mol
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Ponazuril Property

Melting point:
242°
Density 
1.507±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
6.46±0.20(Predicted)
color 
White to Off-White
InChIKey
VBUNOIXRZNJNAD-UHFFFAOYSA-N
CAS DataBase Reference
69004-04-2
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
33816
Product name
Toltrazuril sulfone
Purity
VETRANAL
Packaging
10mg
Price
$323
Updated
2024/03/01
Cayman Chemical
Product number
29655
Product name
Toltrazuril sulfone
Packaging
50mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
29655
Product name
Toltrazuril sulfone
Packaging
250mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
29655
Product name
Toltrazuril sulfone
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29655
Product name
Toltrazuril sulfone
Packaging
100mg
Price
$169
Updated
2024/03/01
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Ponazuril Chemical Properties,Usage,Production

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Ponazuril Preparation Products And Raw materials

Raw materials

Preparation Products

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Ponazuril Suppliers

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View Lastest Price from Ponazuril manufacturers

Sinoway Industrial co., ltd.
Product
Ponazuril ，Toltrazuril sulfone 69004-04-2
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2022-08-25
Hebei Ganmiao New material Technology Co., LTD
Product
Ponazuril 69004-04-2
Price
US $10.00-8.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06
Anhui Yiao New Material Technology Co., Ltd
Product
Toltrazuril sulfone 69004-04-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1 tons
Release date
2023-11-02

69004-04-2, PonazurilRelated Search:

D-Nebivolol,hydrochloride(1:1) Nebivolol Impurity 2 HCl (SR,RS) (+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol Defluoro Nebivolol (Mixture of DiastereoMers) Didefluoro Nebivolol (Mixture of DiastereoMers) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran (-)-Nebivolol Nebivolol Impurity 28 HCl (SS,RS) Nebivolol Impurity 3 Nebivolol Impurity 13 HCl (SS,SS) (2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran Toltrazuril 4-(Trifluoromethylthio)phenol 1-Methyl-3-{3-methyl-4-[4-(trifluormethylsulfinyl)-phenoxy]-phenyl}-1,3,5-triazin-2,4,6(1H,3H,5H)-trion 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE Ponazuril 1-Methanesulfonyl-4-phenoxy-benzene 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE

  • Toltrazuril sulfone Ponazuril
  • 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H
  • Ponazuril
  • ToltrazurilSulfone
  • 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
  • Ponazuril [inn]
  • Unii-jpw84as66u
  • 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
  • Toltrazuril Sulfone Standard
  • 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]phenoxy]phenyl]-
  • Ponazurilr
  • Ponazuril ，Toltrazuril sulfone
  • Veterinary Ponazuril
  • 69004-04-2
  • 9004-04-2
  • C18H14F3N3O6S
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals