ChemicalBook > CAS DataBase List > (+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran

Product Name
(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran
CAS No.
197706-51-7
Chemical Name
(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran
Synonyms
Nebivolol Isomer-A;A-Isomer Nebivolol;Nebivolol Impurity 10;Nebivolol A Isomer (Nebivolol Imp-28);(S)-6-fluoro-2-((R)-oxiran-2-yl)chroman;(2S, 2’R)-6-Fluoro-2-(2’-oxiranyl)chromane;2H-1-Benzopyran, 6-fluoro-3,4-dihydro-2-[(2R)-2-oxiranyl]-, (2S)-
CBNumber
CB74748565
Molecular Formula
C11H11FO2
Formula Weight
194.2
MOL File
197706-51-7.mol
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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Property

Boiling point:
285.4℃ at 102kPa
Density 
1.38g/cm3 at 20℃
vapor pressure 
0.21-0.4Pa at 20-25℃
form 
Solid
LogP
2.5-3.2 at pH7
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

TRC
Product number
F595090
Product name
(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
Packaging
100mg
Price
$1540
Updated
2021/12/16
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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Chemical Properties,Usage,Production

Uses

(2S,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker.

(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran Suppliers

China 24 India 2 United States 1 Global 27
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58

197706-51-7, (+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyranRelated Search:

(+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol Nebivolol Impurity 12 HCl (RR,RR) Defluoro Nebivolol (Mixture of DiastereoMers) Nebivolol Impurity 2 HCl (SR,RS) Didefluoro Nebivolol (Mixture of DiastereoMers) (2R)-rel-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran D-Nebivolol,hydrochloride(1:1) Nebivolol Impurity 13 HCl (SS,SS) (2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran Nebivolol Impurity 28 HCl (SS,RS) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran Ponazuril (-)-Nebivolol Nebivolol Impurity 10 HCl (RS,SR) 4-Hydroxy Nebivolol, Hydrochloride Hydrate (Mixture of Diastereomers) Nebivolol (R,R,S,R)-Isomer Nebivolol Nebivolol Impurity 3

  • (S)-6-fluoro-2-((R)-oxiran-2-yl)chroman
  • (2S, 2’R)-6-Fluoro-2-(2’-oxiranyl)chromane
  • 2H-1-Benzopyran, 6-fluoro-3,4-dihydro-2-[(2R)-2-oxiranyl]-, (2S)-
  • Nebivolol Impurity 10
  • A-Isomer Nebivolol
  • Nebivolol Isomer-A
  • Nebivolol A Isomer (Nebivolol Imp-28)
  • 197706-51-7