5-(4-Fluorophenyl)pyridine-2-carboxylic acid

Product Name: 5-(4-Fluorophenyl)pyridine-2-carboxylic acid
CAS No.: 845826-99-5
Chemical Name: 5-(4-Fluorophenyl)pyridine-2-carboxylic acid
Synonyms: 5-(4-Fluorophenyl)-picolinic acid;5-(3-Chlorophenyl)-picolinic acid;5-(2-Chlorophenyl)-picolinic acid;5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID;5-(4-Fluorophenyl)-2-pyridinecarboxylic acid;5-(4-Fluorophenyl)-pyridin-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(4-fluorophenyl)-;5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID, 95+%
CBNumber: CB7476361
Molecular Formula: C12H8FNO2
Formula Weight: 217.2
MOL File: 845826-99-5.mol

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5-(4-Fluorophenyl)pyridine-2-carboxylic acid Property

Boiling point:: 394.9±32.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 0.92±0.50(Predicted)

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F621275
Product name: 5-(4-Fluorophenyl)picolinicacid
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Matrix Scientific

Product number: 126297
Product name: 5-(4-Fluorophenyl)picolinicacid
Purity: >95%
Packaging: 1g
Price: $314
Updated: 2021/12/16

AK Scientific

Product number: Z5173
Product name: 5-(4-Fluorophenyl)pyridine-2-carboxylicacid
Packaging: 5g
Price: $744
Updated: 2021/12/16

Matrix Scientific

Product number: 126297
Product name: 5-(4-Fluorophenyl)picolinicacid
Purity: >95%
Packaging: 5g
Price: $987
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0003175
Product name: 5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $1030.84
Updated: 2021/12/16

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5-(4-Fluorophenyl)pyridine-2-carboxylic acid Chemical Properties,Usage,Production

Uses

5-(4-Fluorophenyl)picolinic acid

Synthesis

30766-11-1

1765-93-1

845826-99-5

Step A: 5-bromopyridine-2-carboxylic acid (57, 1.0 g, 5.0 mmol) was dissolved in a solvent mixture of ethylene glycol dimethyl ether (12 mL) and water (4 mL). Subsequently, 4-fluorophenylboronic acid (17, 1.0 g, 7.5 mmol), anhydrous potassium carbonate (1.0 g, 7.5 mmol) and tetrakis(triphenylphosphine)palladium (289 mg, 0.25 mmol) were added sequentially. The reaction mixture was stirred at 98 °C for 24 h under nitrogen protection. After the completion of the reaction was monitored by thin layer chromatography (TLC), the reaction solution was cooled to room temperature. Water (40 mL) was added to the reaction solution and the pH was adjusted to 2-3 with 6 M hydrochloric acid solution. the precipitate was collected by filtration, the filter cake was redissolved in dichloromethane, and the organic layer was separated and washed with water. The aqueous phase was again adjusted to pH 2-3 with 6 M hydrochloric acid solution and the solid product was collected by filtration. The filter cake was washed with water to neutral and dried to give the crude product. The crude product was treated with 20 mL of saturated sodium bicarbonate solution to give the final target compound 5-(4-fluorophenyl)pyridine-2-carboxylic acid (61,942 mg) in 87.7% yield.

References

[1] Patent: CN108623532, 2018, A. Location in patent: Paragraph 0206; 0207; 0208
[2] Patent: EP1657242, 2006, A1. Location in patent: Page/Page column 31
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 4, p. 812 - 819
[4] Medicinal Chemistry, 2017, vol. 13, # 2, p. 176 - 185
[5] Medicinal Chemistry Research, 2018, vol. 27, # 2, p. 374 - 387

5-(4-Fluorophenyl)pyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-Fluorophenyl)pyridine-2-carboxylic acid Suppliers

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845826-99-5, 5-(4-Fluorophenyl)pyridine-2-carboxylic acidRelated Search:

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5-(4-FLUOROPHENYL)PYRIDINE-2-CARBOXYLIC ACID, 95+%

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5-(4-Fluorophenyl)-pyridin-2-carboxylic acid

5-(4-Fluorophenyl)-2-pyridinecarboxylic acid

845826-99-5

C12HClNO2

Fluorine series