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Dxd

Product Name
Dxd
CAS No.
1599440-33-1
Chemical Name
Dxd
Synonyms
Dxd (Exatecan derivative);Dxd;OQM5SD32BQ;UNII-OQM5SD32BQ;Dxd, 10 mM in DMSO;Exatecan derivative;Exatecan derivative for ADC;Trastuzumab Deruxtecan (DS-8201a);Dxd (Exatecan derivative for ADC);Dxd,Inhibitor,ADC,ADC Cytotoxin,inhibit,Topoisomerase,HER2-targeting,ADC Payload
CBNumber
CB74796647
Molecular Formula
C26H24FN3O6
Formula Weight
493.48
MOL File
1599440-33-1.mol
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Dxd Property

Boiling point:
957.9±65.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:40.0(Max Conc. mg/mL);81.06(Max Conc. mM)
form 
Solid
pka
11.18±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0044752
Product name
Dxd
Packaging
1mg
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0044752
Product name
Dxd
Packaging
5mg
Price
$1050
Updated
2021/12/16
ChemScene
Product number
CS-0044752
Product name
Dxd
Packaging
10mg
Price
$1360
Updated
2021/12/16
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Dxd Chemical Properties,Usage,Production

Biological Activity

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor with IC50 value of 0.31 μM, which can be used as a payload for an antibody-drug conjugate ADC (DS-8201a) targeting HER2.

in vitro

Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC 50 s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC 50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC 50 , >10,000 ng/mL).

in vivo

DS-8201a (Dxd is the payload, 10 mg/kg, i.v.) shows potent antitumor activity in HER2-positive models with KPL4, JIMT-1, and Capan-1 and in HER2 low-expressing ST565 and ST313 models with HER2 IHC 1+/FISH-negative expression.

Dxd Preparation Products And Raw materials

Raw materials

Preparation Products

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Dxd Suppliers

China 81 India 1 United States 6 Global 88
BTC pharm India
Tel
+918790379245
Email
banny.janga@btcpharm.com
Country
India
ProdList
1262
Advantage
58
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View Lastest Price from Dxd manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Dxd 1599440-33-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

1599440-33-1, DxdRelated Search:


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  • Trastuzumab Deruxtecan (DS-8201a)
  • N-((1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide
  • N-((1S,9S)-9- ethyl -5- fluoro -2,3,9,10,13,15- hexahydro -9- hydroxy -4- methyl -10,13- dioxo -1H,12H- benzo (de) pyrano (3',)
  • Dxd (Exatecan derivative for ADC)
  • Dxd, 10 mM in DMSO
  • 1599440-33-1
  • 599440-33-1