Dxd
- Product Name
- Dxd
- CAS No.
- 1599440-33-1
- Chemical Name
- Dxd
- Synonyms
- Dxd (Exatecan derivative);Dxd;OQM5SD32BQ;UNII-OQM5SD32BQ;Exatecan derivative;Exatecan derivative for ADC;Trastuzumab Deruxtecan (DS-8201a);Dxd,Inhibitor,ADC,ADC Cytotoxin,inhibit,Topoisomerase,HER2-targeting,ADC Payload;N-((1S,9S)-9- ethyl -5- fluoro -2,3,9,10,13,15- hexahydro -9- hydroxy -4- methyl -10,13- dioxo -1H,12H- benzo (de) pyrano (3',);N-((1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl)-2-hydroxyacetamide
- CBNumber
- CB74796647
- Molecular Formula
- C26H24FN3O6
- Formula Weight
- 493.48
- MOL File
- 1599440-33-1.mol
Dxd Property
- Boiling point:
- 957.9±65.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:40.0(Max Conc. mg/mL);81.06(Max Conc. mM)
- pka
- 11.18±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 1mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 5mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 10mg
- Price
- $1360
- Updated
- 2021/12/16
Dxd Chemical Properties,Usage,Production
Biological Activity
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor with IC50 value of 0.31 μM, which can be used as a payload for an antibody-drug conjugate ADC (DS-8201a) targeting HER2.
in vitro
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC 50 s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC 50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC 50 , >10,000 ng/mL).
in vivo
DS-8201a (Dxd is the payload, 10 mg/kg, i.v.) shows potent antitumor activity in HER2-positive models with KPL4, JIMT-1, and Capan-1 and in HER2 low-expressing ST565 and ST313 models with HER2 IHC 1+/FISH-negative expression.
Dxd Preparation Products And Raw materials
Raw materials
Preparation Products
Dxd Suppliers
- Tel
- +918790379245
- banny.janga@btcpharm.com
- Country
- India
- ProdList
- 1269
- Advantage
- 58
View Lastest Price from Dxd manufacturers
- Product
- Dxd 1599440-33-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13