Dxd
- Product Name
- Dxd
- CAS No.
- 1599440-33-1
- Chemical Name
- Dxd
- Synonyms
- Dxd (Exatecan derivative);Dxd;OQM5SD32BQ;UNII-OQM5SD32BQ;Exatecan derivative;Exatecan derivative for ADC;Trastuzumab Deruxtecan (DS-8201a);Dxd,Inhibitor,ADC,ADC Cytotoxin,inhibit,Topoisomerase,HER2-targeting,ADC Payload;N-((1S,9S)-9- ethyl -5- fluoro -2,3,9,10,13,15- hexahydro -9- hydroxy -4- methyl -10,13- dioxo -1H,12H- benzo (de) pyrano (3',);N-((1S,9S)-9- ethyl -5- fluoro -2,3,9,10,13,15- hexahydro -9- hydroxy -4- methyl -10,13- dioxo -1H,12H- benzo (de) pyrano (3',)
- CBNumber
- CB74796647
- Molecular Formula
- C26H24FN3O6
- Formula Weight
- 493.48
- MOL File
- 1599440-33-1.mol
Dxd Property
- Boiling point:
- 957.9±65.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:40.0(Max Conc. mg/mL);81.06(Max Conc. mM)
- pka
- 11.18±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 1mg
- Price
- $520
- Updated
- 2021/12/16
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 5mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CS-0044752
- Product name
- Dxd
- Packaging
- 10mg
- Price
- $1360
- Updated
- 2021/12/16
Dxd Chemical Properties,Usage,Production
Biological Activity
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor with IC50 value of 0.31 μM, which can be used as a payload for an antibody-drug conjugate ADC (DS-8201a) targeting HER2.
in vitro
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC 50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC 50 s of 1.43 nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four cell lines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC 50 values of 26.8, 25.4, and 6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC 50 , >10,000 ng/mL).
in vivo
DS-8201a (Dxd is the payload, 10 mg/kg, i.v.) shows potent antitumor activity in HER2-positive models with KPL4, JIMT-1, and Capan-1 and in HER2 low-expressing ST565 and ST313 models with HER2 IHC 1+/FISH-negative expression.
Dxd Preparation Products And Raw materials
Raw materials
Preparation Products
Dxd Suppliers
- Tel
- 18514007688
- jiaxin.zhao@acrobiosystems.com
- Country
- China
- ProdList
- 821
- Advantage
- 58
- Tel
- 021-50896099 18017206244
- Fax
- QQ:3268640975
- sales@tekanbio.com
- Country
- China
- ProdList
- 102
- Advantage
- 58
- Tel
- 0510-83591909 18018392058
- Fax
- 0510-83591909
- info@enbridgepharm.com
- Country
- China
- ProdList
- 180
- Advantage
- 58
- Tel
- 0512-81877925 051281877925
- info@levena.cn
- Country
- China
- ProdList
- 48
- Advantage
- 58
- Tel
- 0513-15251351988 15251351988
- 3686954964@qq.com
- Country
- China
- ProdList
- 372
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9452
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17993
- Advantage
- 56
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4182
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8015
- Advantage
- 62
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- 027-027-83778875 15807197853
- Fax
- 027-83991220
- 15807197853@163.com
- Country
- China
- ProdList
- 3980
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1011
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- +86-021-51783479 +86-13816874662
- Fax
- 021-50800795
- info@shochem.com
- Country
- China
- ProdList
- 295
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10523
- Advantage
- 58
- Tel
- 571-86758373 +8613588754946
- Fax
- 0086-571-81131109
- sales@huarongpharm.com
- Country
- CHINA
- ProdList
- 3149
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5182
- Advantage
- 58
- Tel
- 0510-0510-86838766
- 2258830676@qq.com
- Country
- China
- ProdList
- 3834
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 18616665298
- wenjie.li@bocimed.com
- Country
- China
- ProdList
- 226
- Advantage
- 58
- Tel
- +86-021-021-50872116 +8613122107989
- contact@fuxinpharm.com
- Country
- China
- ProdList
- 10297
- Advantage
- 58
- Tel
- 0531-88762217 18301471076
- sales@acespharma.com
- Country
- China
- ProdList
- 3863
- Advantage
- 58
- Tel
- 13522808617
- omiget@qq.com
- Country
- China
- ProdList
- 9213
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3614
- Advantage
- 58
- Tel
- 0571-89903882 13626641628
- jiangnan@huidabiotech.com
- Country
- China
- ProdList
- 3656
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10010
- Advantage
- 58
- Tel
- 021-52919136 17315815539
- 2804155403@qq.com
- Country
- China
- ProdList
- 169
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 8284
- Advantage
- 58
- Tel
- 027-68897569 18120462897
- Fax
- 027-68897569
- fiona@yuanmengbio.com
- Country
- China
- ProdList
- 431
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 15720605021
- Fax
- QQ:353175721
- zhang_lei@jsnchem.com
- Country
- China
- ProdList
- 1514
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7973
- Advantage
- 58
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
- Country
- China
- ProdList
- 3705
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6637
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
- Country
- China
- ProdList
- 63720
- Advantage
- 58
- Tel
- 17691182729 18161915376
- 1046@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24017
- Advantage
- 58
- Tel
- 027-59105166 13125137732
- 2853863890@qq.com
- Country
- China
- ProdList
- 2936
- Advantage
- 58
- Tel
- 0371-53370800 18037197114
- 2853031799@qq.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 2780
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27996
- Advantage
- 58
- Tel
- 15868607770
- hstysales@126.com
- Country
- China
- ProdList
- 1163
- Advantage
- 58
- Tel
- 15801958784
- lihua@jskchem.com
- Country
- China
- ProdList
- 49242
- Advantage
- 58
- Tel
- 4000255188
- sun_dan@PharmaBlock.com
- Country
- China
- ProdList
- 7268
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- cb5@aikonchem.com
- Country
- China
- ProdList
- 10529
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29990
- Advantage
- 58
- Tel
- 13053322091 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10974
- Advantage
- 58
View Lastest Price from Dxd manufacturers
- Product
- Dxd 1599440-33-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13