ChemicalBook > CAS DataBase List > Escitalopram Impurity

Escitalopram Impurity

Product Name
Escitalopram Impurity
CAS No.
1363421-46-8
Chemical Name
Escitalopram Impurity
Synonyms
MOMIPP;MOMIPP, 10 mM in DMSO;Escitalopram Impurity;(2E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one;(E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one;2-Propen-1-one, 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-, (2E)-;inhibit,Inhibitor,JNK1/2,BBB,Fab1,c-Jun,MOMIPP,Bcl-2,PIKfyve,Macropinocytosis,Bcl-xL
CBNumber
CB74808557
Molecular Formula
C18H16N2O2
Formula Weight
292.33
MOL File
1363421-46-8.mol
More
Less

Escitalopram Impurity Property

Boiling point:
521.0±50.0 °C(Predicted)
Density 
1.239±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C)
pka
16.05±0.30(Predicted)
form 
Solid
color 
Yellow to orange
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb546253
Product name
MOMIPP
Purity
>98%
Packaging
10mg
Price
$146.2
Updated
2021/12/16
Biorbyt Ltd
Product number
orb546253
Product name
MOMIPP
Purity
>98%
Packaging
50mg
Price
$307.7
Updated
2021/12/16
More
Less

Escitalopram Impurity Chemical Properties,Usage,Production

Uses

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

in vivo

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].

Animal Model:Athymic CrTac:NCR-Foxn1 mice (female, 7-8weeks)[2]
Dosage:80mg/kg
Administration:i.p.; once daily; for 15 consecutive days
Result:Suppressed progression of intracerebral glioblastoma xenografts.

References

[1] Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. DOI:10.3390/cancers11030411
[2] Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. DOI:10.1186/s12885-019-5288-y

Escitalopram Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Escitalopram Impurity Suppliers

China 24 United States 2 Global 26
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
sales@linyuepharm.com
Country
China
ProdList
5534
Advantage
55
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3290
Advantage
58
Chengdu Gelingsu Biotechnology Co., Ltd.
Tel
18508196360 1355086427
Fax
028-82731617
Email
hongsong0209@163.com
Country
China
ProdList
86
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32469
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4998
Advantage
58
Jinan Jiuli Biotechnology Co. , Ltd.
Tel
15865264761
Email
486064515@qq.com
Country
China
ProdList
4880
Advantage
58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
690231469@qq.com
Country
China
ProdList
8100
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24962
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58

1363421-46-8, Escitalopram ImpurityRelated Search:

1-[3-(DIMETHYLAMINO)PROPYL]-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBOXAMIDE 4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)-3-hydroxymethyl) benzonitrile hydrochloride 3-Oxo Citalopram 1,3-dihydro-1-oxoisobenzofuran-5-carboxamide Escitalopram oxalate Citalopram (+/-)-4-[4-(diMethylaMino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyMethyl)-benzonitrile, oxalate 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile 4-(4-fluorobenzoyl)-3-(hydroxyMethyl)benzonitrile (-)-4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

  • MOMIPP
  • (E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one
  • inhibit,Inhibitor,JNK1/2,BBB,Fab1,c-Jun,MOMIPP,Bcl-2,PIKfyve,Macropinocytosis,Bcl-xL
  • 2-Propen-1-one, 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-, (2E)-
  • Escitalopram Impurity
  • MOMIPP, 10 mM in DMSO
  • (2E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one
  • 1363421-46-8