Escitalopram Impurity

Product Name: Escitalopram Impurity
CAS No.: 1363421-46-8
Chemical Name: Escitalopram Impurity
Synonyms: MOMIPP;MOMIPP, 10 mM in DMSO;Escitalopram Impurity;(2E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one;(E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one;2-Propen-1-one, 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-, (2E)-;inhibit,Inhibitor,JNK1/2,BBB,Fab1,c-Jun,MOMIPP,Bcl-2,PIKfyve,Macropinocytosis,Bcl-xL
CBNumber: CB74808557
Molecular Formula: C18H16N2O2
Formula Weight: 292.33
MOL File: 1363421-46-8.mol

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Escitalopram Impurity Property

Boiling point:: 521.0±50.0 °C(Predicted)
Density: 1.239±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C)
pka: 16.05±0.30(Predicted)
form: Solid
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb546253
Product name: MOMIPP
Purity: >98%
Packaging: 10mg
Price: $146.2
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546253
Product name: MOMIPP
Purity: >98%
Packaging: 50mg
Price: $307.7
Updated: 2021/12/16

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Escitalopram Impurity Chemical Properties,Usage,Production

Uses

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2].

in vivo

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts^[2].

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8?weeks)^[2]
Dosage:	80?mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

References

[1] Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. DOI:10.3390/cancers11030411
[2] Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. DOI:10.1186/s12885-019-5288-y

Escitalopram Impurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Escitalopram Impurity Suppliers

China 23 United States 2 Global 25

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1363421-46-8, Escitalopram ImpurityRelated Search:

1-[3-(DIMETHYLAMINO)PROPYL]-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBOXAMIDE 4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)-3-hydroxymethyl) benzonitrile hydrochloride 3-Oxo Citalopram 1,3-dihydro-1-oxoisobenzofuran-5-carboxamide Escitalopram oxalate Citalopram (+/-)-4-[4-(diMethylaMino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyMethyl)-benzonitrile, oxalate 4-(bis(4-fluorophenyl)(hydroxy)Methyl) -3-(hydroxyMethyl)benzonitrile 4-(4-fluorobenzoyl)-3-(hydroxyMethyl)benzonitrile (-)-4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile 4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile

MOMIPP

(E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one

inhibit,Inhibitor,JNK1/2,BBB,Fab1,c-Jun,MOMIPP,Bcl-2,PIKfyve,Macropinocytosis,Bcl-xL

2-Propen-1-one, 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-, (2E)-

Escitalopram Impurity

MOMIPP, 10 mM in DMSO

(2E)-3-(5-Methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one

1363421-46-8