GO 289)
- Product Name
- GO 289)
- CAS No.
- 694522-87-7
- Chemical Name
- GO 289)
- Synonyms
- GO 289);(E/Z） O289;(EZ)-GO289;GO289 (GO-289;(E/Z)-GO289, 10 mM in DMSO;5-Bromo-2-methoxy-4-(((3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl)imino)methyl)phenol;Phenol, 5-bromo-2-methoxy-4-[[[3-(methylthio)-5-phenyl-4H-1,2,4-triazol-4-yl]imino]methyl]-;Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,phosphorylation,(E/Z)-GO289,Casein Kinase,inhibit
- CBNumber
- CB74844814
- Molecular Formula
- C17H15BrN4O2S
- Formula Weight
- 419.3
- MOL File
- 694522-87-7.mol
GO 289) Property
- Boiling point:
- 618.0±65.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2mg/mL, clear
- pka
- 7.53±0.40(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- SML3447
- Product name
- GO289
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $132
- Updated
- 2024/03/01
- Product number
- SML3447
- Product name
- GO289
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $426
- Updated
- 2024/03/01
- Product number
- G767505
- Product name
- GO289
- Packaging
- 50mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- G767505
- Product name
- GO289
- Packaging
- 100mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- G767505
- Product name
- GO289
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
GO 289) Chemical Properties,Usage,Production
Uses
GO289, is a new potent and highly selective CK2 inhibitor, which strongly lengthens circadian period. It inhibits multiple phsphorylation sites on clock proteins, including PER2 S693. GO289, also exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function.
Biological Activity
GO289 is a highly potent and selective casein kinase CK2 (CKII) inhibitor (IC50 = 7 nM/CK2, 13 μM/PIM2, >50 μM/CLK2; <50% inhibition of CK1α/δ/γ and 56 other kinases at 5 μM) th at targets CK2-specific residues (CK2α V66, M163, and H160) with more overall interactions at the CK2 ATP-binding pocket than TBB, DM at & CX-4945. GO289 selectively inhibits cellular CK1 substrates phosphorylation (0.8-8 μM; HEK293T, U2OS), including clock proteins PER2, CRY1, CLOCK & BMAL1, and displays circadian period-lengthening (Bmal1-dLuc USOS EC50 = 3.3 μM) as well as growth inhibitory potency in CK2-dependent human renal cell carcinoma (RCC) cultures.
GO 289) Preparation Products And Raw materials
Raw materials
Preparation Products
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