6-METHOXY-3-METHYL-1H-INDAZOLE
- Product Name
- 6-METHOXY-3-METHYL-1H-INDAZOLE
- CAS No.
- 7746-29-4
- Chemical Name
- 6-METHOXY-3-METHYL-1H-INDAZOLE
- Synonyms
- 6-Methoxy-3-methylindazole;3-METHYL-6-METHOXY 1H-INDAZOLE;6-METHOXY-3-METHYL-1H-INDAZOLE;1H-Indazole, 6-methoxy-3-methyl-
- CBNumber
- CB7487659
- Molecular Formula
- C9H10N2O
- Formula Weight
- 162.19
- MOL File
- 7746-29-4.mol
6-METHOXY-3-METHYL-1H-INDAZOLE Property
- Melting point:
- 168-169 °C
- Boiling point:
- 323.0±22.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.68±0.40(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M337578
- Product name
- 6-Methoxy-3-methyl-1H-indazole
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 072398
- Product name
- 6-Methoxy-3-methyl-1H-indazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- CHM0094370
- Product name
- 3-METHYL-6-METHOXY 1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $933.24
- Updated
- 2021/12/16
- Product number
- CHM0094370
- Product name
- 3-METHYL-6-METHOXY 1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1346.73
- Updated
- 2021/12/16
- Product number
- CHM0094370
- Product name
- 3-METHYL-6-METHOXY 1H-INDAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2674.98
- Updated
- 2021/12/16
6-METHOXY-3-METHYL-1H-INDAZOLE Chemical Properties,Usage,Production
Uses
6-Methoxy-3-methyl-1H-indazole is a pharmaceutical intermediate compound that is used in the preparation of EGFR inhibitors.
Synthesis
74457-86-6
7746-29-4
General procedure for the synthesis of 6-methoxy-3-methyl-1H-indazole from 2-fluoro-4-methoxyacetophenone: 1-(2-fluoro-4-methoxyphenyl)ethan-1-one (2 g, 11.9 mmol) was dissolved in a mixture of 5 mL of hydrazine hydrate (85%) and N-methylpyrrolidone (NMP, 15 mL). The reaction mixture was stirred at 120°C for 24 hours. After completion of the reaction, the product was purified by column chromatography to afford 6-methoxy-3-methyl-1H-indazole (1.5 g, 78% yield).
References
[1] Patent: WO2016/8590, 2016, A1. Location in patent: Page/Page column 50
[2] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0365; 0366
[3] Patent: US6956036, 2005, B1
[4] Patent: US6552062, 2003, B1
[5] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 49-50
6-METHOXY-3-METHYL-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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