ChemicalBook > CAS DataBase List > 4-FLUORO-3-NITROBENZYL ALCOHOL 96

4-FLUORO-3-NITROBENZYL ALCOHOL 96

Product Name
4-FLUORO-3-NITROBENZYL ALCOHOL 96
CAS No.
20274-69-5
Chemical Name
4-FLUORO-3-NITROBENZYL ALCOHOL 96
Synonyms
(4-Fluoro-3-nitrophenyl)methanol;Benzenemethanol, 4-fluoro-3-nitro-;4-Fluoro-3-nitrobenzyl alcohol 96%;4-FLUORO-3-NITROBENZYL ALCOHOL 96
CBNumber
CB7500271
Molecular Formula
C7H6FNO3
Formula Weight
171.13
MOL File
20274-69-5.mol
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4-FLUORO-3-NITROBENZYL ALCOHOL 96 Property

Melting point:
39-44 °C (lit.)
Boiling point:
333.7±27.0 °C(Predicted)
Density 
1.434
Flash point:
230 °F
storage temp. 
Sealed in dry,Room Temperature
pka
13.37±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
526916
Product name
4-Fluoro-3-nitrobenzyl alcohol
Purity
96%
Packaging
5g
Price
$168
Updated
2023/06/20
TRC
Product number
F594705
Product name
4-Fluoro-3-nitrobenzyl alcohol
Packaging
25g
Price
$525
Updated
2021/12/16
AK Scientific
Product number
X4256
Product name
4-Fluoro-3-nitrobenzyl alcohol
Packaging
1g
Price
$33
Updated
2021/12/16
ChemScene
Product number
CS-W017657
Product name
4-Fluoro-3-nitrobenzyl alcohol
Packaging
5g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC502598
Product name
4-Fluoro-3-nitrobenzyl alcohol
Packaging
1g
Price
$102
Updated
2021/12/16
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4-FLUORO-3-NITROBENZYL ALCOHOL 96 Chemical Properties,Usage,Production

Uses

4-Fluoro-3-nitrobenzyl Alcohol is used as a reagent in the preparation of EW-7197 (E950000) which is a highly potent orally bioavailable inhibitor of TGF-β type I receptor kinase that is used in cancer treatment as an immunotherapeutic or antifibrotic agent.

Uses

4-Fluoro-3-nitrobenzyl alcohol may be used in the synthesis of 4-fluoro-3-nitrobenzyl chloride.

General Description

4-Fluoro-3-nitrobenzyl alcohol can be prepared from the reaction between borane (in THF) and 4-fluoro-3-nitrobenzoic acid (in THF) at 0°C.

Synthesis

453-71-4

20274-69-5

The general procedure for the synthesis of 3-nitro-4-fluorobenzyl alcohol from 4-fluoro-3-nitrobenzoic acid was as follows: sodium borohydride (2.70 g, 64.83 mmol) was dissolved in 100 mL of tetrahydrofuran and cooled to 0 °C. 4-Fluoro-3-nitrobenzoic acid (12.0 g, 64.83 mmol) was added in batches at 0 °C and the addition process lasted for 1 hour. Subsequently, boron trifluoride diethyl ether solution (6.55 mL, 71.31 mmol) was added dropwise at 0 °C. The reaction mixture was slowly warmed to room temperature and stirring was continued for 3 hours. Upon completion of the reaction, 500 mL of ethyl acetate and 300 mL of water were added to the mixture, which was layered and the organic phase was collected. The organic phase was washed with 500 mL of saturated sodium chloride solution and then dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to give 3-nitro-4-fluorobenzyl alcohol (11.0 g, light yellow solid) in 99.1% yield.

References

[1] Patent: CN107400092, 2017, A. Location in patent: Paragraph 0293; 0295-0298
[2] Patent: CN108264511, 2018, A. Location in patent: Paragraph 0280; 0283-0286
[3] Patent: WO2012/171488, 2012, A1. Location in patent: Page/Page column 22-23
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 23, p. 5546 - 5550
[5] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 54

4-FLUORO-3-NITROBENZYL ALCOHOL 96 Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-3-NITROBENZYL ALCOHOL 96 Suppliers

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View Lastest Price from 4-FLUORO-3-NITROBENZYL ALCOHOL 96 manufacturers

Career Henan Chemical Co
Product
4-FLUORO-3-NITROBENZYL ALCOHOL 96 20274-69-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-08

20274-69-5, 4-FLUORO-3-NITROBENZYL ALCOHOL 96Related Search:

4-Fluoro-3-nitrobenzyl bromide 4-Fluoro-3-nitrobenzoic acid 4-FLUORO-3-NITRO-5-(TRIFLUOROMETHYL)BENZOIC ACID 3-Nitrobenzyl alcohol Methyl 4-fluoro-3-nitrobenzoate 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID 2,4-DIFLUORO-5-NITROBENZOIC ACID 4-FLUORO-3-NITROBENZYL ALCOHOL 96 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER METHYL 2-CHLORO-4-FLUORO-5-NITROBENZOATE 2,3,4-Trifluoro-5-Nitro-Benzoic Acid 2-FLUORO-5-NITROBENZYL ALCOHOL 96 2,4,5-TRIFLUORO-3-NITROBENZOIC ACID N-(5-(ethoxy(imino)methyl)-2-fluorophenyl)-N-oxohydroxylammonium RARECHEM AL BP 0858 N-(5-(ethoxy(imino)methyl)-2,4-difluorophenyl)-N-oxohydroxylammonium 4-FLUORO-3-NITROMETHYLBENZOATE, [CARBONYL-14C]-

  • 4-FLUORO-3-NITROBENZYL ALCOHOL 96
  • (4-Fluoro-3-nitrophenyl)methanol
  • 4-Fluoro-3-nitrobenzyl alcohol 96%
  • Benzenemethanol, 4-fluoro-3-nitro-
  • 20274-69-5
  • FC6H3NO2CH2OH
  • Alcohol
  • Alcohols
  • C7 to C8
  • Oxygen Compounds