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RAC 8-HYDROXY EFAVIRENZ

Product Name
RAC 8-HYDROXY EFAVIRENZ
CAS No.
205754-33-2
Chemical Name
RAC 8-HYDROXY EFAVIRENZ
Synonyms
8-HydroxyEfavirenz;RAC 8-HYDROXY EFAVIRENZ;Efavirenz Impurity 11(8-Hydroxy Efavirenz);(4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz
CBNumber
CB7501021
Molecular Formula
C14H9ClF3NO3
Formula Weight
331.67
MOL File
205754-33-2.mol
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RAC 8-HYDROXY EFAVIRENZ Property

Melting point:
144-154°C
Boiling point:
373.6±42.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Acetonitrile: soluble; DMSO: soluble; Methanol: soluble
form 
A solid
pka
7.18±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27853
Product name
8-hydroxy Efavirenz
Packaging
1mg
Price
$605
Updated
2024/03/01
Usbiological
Product number
H9044-30
Product name
rac 8-Hydroxy Efavirenz
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
H941830
Product name
8-HydroxyEfavirenz(~90%)
Packaging
2.5mg
Price
$6595
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010043
Product name
8-HYDROXYEFAVIRENZ
Purity
95.00%
Packaging
1MG
Price
$446.25
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010043
Product name
8-HYDROXYEFAVIRENZ
Purity
95.00%
Packaging
5MG
Price
$504.72
Updated
2021/12/16
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RAC 8-HYDROXY EFAVIRENZ Chemical Properties,Usage,Production

Description

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.

Chemical Properties

Off-White Solid

Uses

A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor

Uses

8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

RAC 8-HYDROXY EFAVIRENZ Preparation Products And Raw materials

Raw materials

Preparation Products

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RAC 8-HYDROXY EFAVIRENZ Suppliers

Canada 1 China 21 Germany 1 India 3 United States 5 Global 31
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14336
Advantage
58

205754-33-2, RAC 8-HYDROXY EFAVIRENZRelated Search:

SE 563 Efavirenz AMino Alcohol Ethyl CarbaMate rac Methyl Efavirenz Efavirenz Related Compound B (15 mg) ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) rac 8-Hydroxy Efavirenz Efavirenz Related Compound C (20 mg) (6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline) 6-chloro-4-pent-1-ynyl-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one L 741211 Efavirenz rac 8,14-Dihydroxy Efavirenz (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine (Mixture of 2 Diastereomers) Efavirenz IP Impurity A rac 7-Hydroxy Efavirenz [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester (S)-5-chloro-a-(Cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-a- (trifluoromethyl) benzenemethanol (E-4) Enantiomer Efavirenz Efavirenz Impurity 13(7-Hydroxy Efavirenz)

  • RAC 8-HYDROXY EFAVIRENZ
  • 8-HydroxyEfavirenz
  • 6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • (4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
  • Efavirenz Impurity 11(8-Hydroxy Efavirenz)
  • 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-
  • 8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz
  • 2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-
  • 205754-33-2
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Metabolites
  • Non-nucleoside Reverse Transcriptase
  • Pharmaceuticals