TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98

Product Name: TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
CAS No.: 845306-08-3
Chemical Name: TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
Synonyms: tert-butyl 5-bromopicolinate;5-Bromopicolinic acid tert-butyl ester;TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98;tert-Butyl 5-bromopyridine-2-carboxylate 98%;5-Bromopyridine-2-carboxylic acid t-butyl ester;2-Methyl-2-propanyl 5-bromo-2-pyridinecarboxylate;5-Bromo-pyridine-2-carboxylic acid tert-butyl ester;5-Bromo-2-pyridinecarboxylic acid 1,1-dimethylethyl ester;2-Pyridinecarboxylic acid, 5-broMo-, 1,1-diMethylethyl ester;TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 ISO 9001：2015 REACH
CBNumber: CB7501304
Molecular Formula: C10H12BrNO2
Formula Weight: 258.11
MOL File: 845306-08-3.mol

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TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Property

Melting point:: 92-94
Boiling point:: 318℃
Density: 1.385
Flash point:: 146℃
storage temp.: Inert atmosphere,Room Temperature
pka: -0.52±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H12BrNO2/c1-10(2,3)14-9(13)8-5-4-7(11)6-12-8/h4-6H,1-3H3
InChIKey: GBAJDPJECJPPSP-UHFFFAOYSA-N
SMILES: C1(C(OC(C)(C)C)=O)=NC=C(Br)C=C1

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Safety

Hazard Codes: Xi
Hazard Note: Irritant/Keep Cold
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B690538
Product name: t-Butyl5-bromopicolinate
Packaging: 1g
Price: $240
Updated: 2021/12/16

Matrix Scientific

Product number: 116379
Product name: tert-Butyl 5-bromopyridine-2-carboxylate
Purity: >97%
Packaging: 500mg
Price: $133
Updated: 2021/12/16

Matrix Scientific

Product number: 116379
Product name: tert-Butyl 5-bromopyridine-2-carboxylate
Purity: >97%
Packaging: 1g
Price: $181
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-9-29
Product name: tert-Butyl 5-bromopyridine-2-carboxylate
Purity: 98%
Packaging: 1g
Price: $192
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0014358
Product name: TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $752.14
Updated: 2021/12/16

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TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Chemical Properties,Usage,Production

Synthesis

30766-11-1

75-65-0

845306-08-3

The general procedure for the synthesis of tert-butyl 5-bromopyridine-2-carboxylate from 2-carboxylic acid-5-bromopyridine and tert-butanol was as follows: 2-carboxylic acid-5-bromopyridine (118 mg, 0.58 mmol) was mixed with pyridine (0.3 mL, 0.39 mmol) and tert-butanol (1 mL), and p-toluenesulfonyl chloride (262 mg, 1.38 mmol) was subsequently added. The reaction mixture was stirred at 40°C for 10 minutes and then continued to stir at room temperature for 2 hours. After the reaction was completed, saturated sodium bicarbonate solution (4 mL) was added and stirred for 5 minutes. Then diethyl ether was added and the two-phase mixture was stirred for 10 minutes. The organic layer was separated, washed with brine, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being pentane: ethyl acetate (100:0 to 80:20) to afford tert-butyl 5-bromopyridine-2-carboxylate as a colorless solid in 73% (110 mg) yield. The product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 1.65 (s, 9H), 7.95 (m, 2H), 8.88 (m, 1H). The mass spectrum (ES+) showed m/z 539 [M2Na]+.

References

[1] Patent: EP1595881, 2005, A1. Location in patent: Page/Page column 62
[2] Patent: WO2005/14571, 2005, A1. Location in patent: Page/Page column 27
[3] Patent: WO2006/29906, 2006, A1. Location in patent: Page/Page column 16-17
[4] Patent: WO2012/143599, 2012, A1. Location in patent: Page/Page column 47-48

TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 Suppliers

China 86 Germany 1 India 1 United Kingdom 1 United States 11 Global 100

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View Lastest Price from TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 manufacturers

Dideu Industries Group Limited

Product: TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 845306-08-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-23

Shaanxi Dideu Medichem Co. Ltd

Product: Tert-Butyl 5-Bromopyridine-2-Carboxylate 845306-08-3
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

845306-08-3, TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98Related Search:

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TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98

5-Bromopyridine-2-carboxylic acid t-butyl ester

5-Bromo-pyridine-2-carboxylic acid tert-butyl ester

tert-Butyl 5-bromopyridine-2-carboxylate 98%

tert-butyl 5-bromopicolinate

2-Pyridinecarboxylic acid, 5-broMo-, 1,1-diMethylethyl ester

5-Bromo-2-pyridinecarboxylic acid 1,1-dimethylethyl ester

5-Bromopicolinic acid tert-butyl ester

TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 ISO 9001：2015 REACH

2-Methyl-2-propanyl 5-bromo-2-pyridinecarboxylate

845306-08-3

blocks

Bromides

Carboxes

Pyridines