ChemicalBook > CAS DataBase List > BP 897

BP 897

Product Name
BP 897
CAS No.
314776-92-6
Chemical Name
BP 897
Synonyms
BP897/BP-897;BP 897 (hydrochloride);BP897 >98% (HPLC), solid;BP 897 hydrochloride, 10 mM in DMSO;N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide;N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride;N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride;Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
CBNumber
CB7503212
Molecular Formula
C26H31N3O2
Formula Weight
417.55
MOL File
314776-92-6.mol
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BP 897 Property

storage temp. 
2-8°C
solubility 
DMSO: 10 mg/mL, soluble
form 
solid
color 
off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B9308
Product name
BP897
Purity
>98% (HPLC), solid
Packaging
5mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
25831
Product name
BP-897
Packaging
1mg
Price
$30
Updated
2024/03/01
Cayman Chemical
Product number
25831
Product name
BP-897
Packaging
25mg
Price
$246
Updated
2024/03/01
Cayman Chemical
Product number
25831
Product name
BP-897
Packaging
5mg
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
25831
Product name
BP-897
Packaging
10mg
Price
$132
Updated
2024/03/01
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BP 897 Chemical Properties,Usage,Production

Description

BP-897 is a dopamine D3 receptor partial agonist. It selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α1- and α2-adrenergic receptors (Kis = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT7 (Kis = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (Kis = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC50 = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D3 receptor antagonist nafadotride. It also acts as a dopamine D3 receptor antagonist, failing to increase [35S]GTPγS binding to CHO cell membranes expressing the recombinant human D3 receptor and inhibiting the effect of dopamine in the same assay (IC50 = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.

Biochem/physiol Actions

Partially selective D3 dopamine receptor agonist.

BP 897 Preparation Products And Raw materials

Raw materials

Preparation Products

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BP 897 Suppliers

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314776-92-6, BP 897Related Search:


  • BP897/BP-897
  • N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride
  • N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide
  • BP897 >98% (HPLC), solid
  • N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride
  • BP 897 (hydrochloride)
  • Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
  • BP 897 hydrochloride, 10 mM in DMSO
  • 314776-92-6
  • C26H32ClN3O2
  • C26H31N3O2HCl