BP 897 Property

storage temp. 

2-8°C

solubility 

DMSO: 10 mg/mL, soluble

form 

solid

color 

off-white

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

BP 897 Chemical Properties,Usage,Production

Description

BP-897 is a dopamine D₃ receptor partial agonist. It selectively binds to the dopamine D₃ over the D₂, D₁, and D₄ receptors (K_is = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α₁- and α₂-adrenergic receptors (K_is = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT₇ (K_is = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (K_is = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC₅₀ = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D₃ receptor antagonist nafadotride. It also acts as a dopamine D₃ receptor antagonist, failing to increase [³⁵S]GTPγS binding to CHO cell membranes expressing the recombinant human D₃ receptor and inhibiting the effect of dopamine in the same assay (IC₅₀ = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.

Biochem/physiol Actions

Partially selective D3 dopamine receptor agonist.