ChemicalBook > CAS DataBase List > BP 897

BP 897

Product Name: BP 897
CAS No.: 314776-92-6
Chemical Name: BP 897
Synonyms: BP897/BP-897;BP 897 (hydrochloride);BP897 >98% (HPLC), solid;BP 897 hydrochloride, 10 mM in DMSO;N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide;N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride;N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride;Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
CBNumber: CB7503212
Molecular Formula: C26H31N3O2
Formula Weight: 417.55
MOL File: 314776-92-6.mol

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BP 897 Property

storage temp.: 2-8°C
solubility: DMSO: 10 mg/mL, soluble
form: solid
color: off-white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B9308
Product name: BP897
Purity: >98% (HPLC), solid
Packaging: 5mg
Price: $156
Updated: 2025/07/31

Cayman Chemical

Product number: 25831
Product name: BP-897
Packaging: 1mg
Price: $30
Updated: 2024/03/01

Cayman Chemical

Product number: 25831
Product name: BP-897
Packaging: 25mg
Price: $246
Updated: 2024/03/01

Cayman Chemical

Product number: 25831
Product name: BP-897
Packaging: 5mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 25831
Product name: BP-897
Packaging: 10mg
Price: $132
Updated: 2024/03/01

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BP 897 Chemical Properties,Usage,Production

Description

BP-897 is a dopamine D₃ receptor partial agonist. It selectively binds to the dopamine D₃ over the D₂, D₁, and D₄ receptors (K_is = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α₁- and α₂-adrenergic receptors (K_is = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT₇ (K_is = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (K_is = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC₅₀ = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D₃ receptor antagonist nafadotride. It also acts as a dopamine D₃ receptor antagonist, failing to increase [³⁵S]GTPγS binding to CHO cell membranes expressing the recombinant human D₃ receptor and inhibiting the effect of dopamine in the same assay (IC₅₀ = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.

Uses

BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1].

Biochem/physiol Actions

Partially selective D3 dopamine receptor agonist.

in vivo

BP 897 hydrochloride binds to D2-receptor in mouse striatum with an ED₅₀ of 15 mg/kg, and the D3-receptor occupancy is blow 0.5 mg/kg^[1].

Animal Model:	Male Listar hooded rats^[1]
Dosage:	0.05, 0.5, 1 mg/kg
Administration:	i.p.; 30 min before the session
Result:	Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.

IC 50

D₂ Receptor; D₃ Receptor

References

[1] Pilla M, et al. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. Nature. 1999 Jul 22;400(6742):371-5. DOI:10.1038/22560

BP 897 Preparation Products And Raw materials

Raw materials

Preparation Products

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BP 897 Suppliers

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314776-92-6, BP 897Related Search:

BP897/BP-897

N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride

N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide

BP897 >98% (HPLC), solid

N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride

BP 897 (hydrochloride)

Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897

BP 897 hydrochloride, 10 mM in DMSO

314776-92-6

C26H32ClN3O2

C26H31N3O2HCl