ChemicalBook > CAS DataBase List > 7-Hydroxy-1,2,3,4-tetrahydroquinoline

7-Hydroxy-1,2,3,4-tetrahydroquinoline

Product Name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
CAS No.
58196-33-1
Chemical Name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Synonyms
Venadaparib Impurity 56;1,2,3,4-Tetrahydro-7-quinolinol;1,2,3,4-Tetrahydro-quinolin-7-ol;7-Quinolinol, 1,2,3,4-tetrahydro-;7-Hydroxy-1,2,3,4-tetrahydroquinoL;7-hydroxy-1,2,3,4-Tetrahydro-quinolin;7-Hydroxy-1,2,3,4-tetrahydroquinoline;7-Hydroxy-1,2,3,4-tetrahydroquinoline1;7-Hydroxy-1,2,3,4-Tetrahydro Quinolinoe;7-Hydroxy-1,2,3,4-tetrahydroquinoline ISO 9001：2015 REACH
CBNumber
CB7511736
Molecular Formula
C9H11NO
Formula Weight
149.19
MOL File
58196-33-1.mol
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7-Hydroxy-1,2,3,4-tetrahydroquinoline Property

Melting point:
70-80 °C
Boiling point:
319.7±31.0 °C(Predicted)
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
pka
10.70±0.20(Predicted)
form 
Solid
color 
Dark Orange to Very Dark Orange
Stability:
Light Sensitive
InChI
InChI=1S/C9H11NO/c11-8-4-3-7-2-1-5-10-9(7)6-8/h3-4,6,10-11H,1-2,5H2
InChIKey
HJJRGZMJZDSMDB-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(O)=C2)CCC1
CAS DataBase Reference
58196-33-1(CAS DataBase Reference)
EPA Substance Registry System
7-Quinolinol, 1,2,3,4-tetrahydro- (58196-33-1)
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Safety

HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H957860
Product name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR952616
Product name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Purity
98%
Packaging
5g
Price
$148
Updated
2021/12/16
Apolloscientific
Product number
OR952616
Product name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Purity
98%
Packaging
1g
Price
$41
Updated
2021/12/16
Matrix Scientific
Product number
072901
Product name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Purity
95+%
Packaging
1g
Price
$59
Updated
2021/12/16
Matrix Scientific
Product number
072901
Product name
7-Hydroxy-1,2,3,4-tetrahydroquinoline
Purity
95+%
Packaging
5g
Price
$188
Updated
2021/12/16
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7-Hydroxy-1,2,3,4-tetrahydroquinoline Chemical Properties,Usage,Production

Synthesis

22246-18-0

58196-33-1

The general procedure for the synthesis of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 3,4-dihydro-7-hydroxy-2(1H)-quinolinone was as follows: 7-hydroxy-3,4-dihydroquinolin-2(1H)-one (2.00 g, 12.26 mmol) was dissolved in tetrahydrofuran (THF, 20 mL) and the solution was cooled down to 0 °C. Subsequently, sodium borohydride (NaBH4, 1.07 g, 28.19 mmol) was added, and then iodine (I2, 3.42 g, 13.48 mmol) dissolved in THF (20 mL) was slowly added dropwise through the addition funnel to the reaction mixture. After installing the condenser, the reaction mixture was refluxed overnight. After completion of the reaction, the reaction mixture was neutralized with 3 M hydrochloric acid solution and then extracted three times with dichloromethane. The organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a viscous yellow oil. Finally, the crude product was purified by fast column chromatography to afford 7-hydroxy-1,2,3,4-tetrahydroquinoline as a white crystalline solid (1.80 g, 98% yield).

References

[1] Angewandte Chemie - International Edition, 2013, vol. 52, # 2, p. 650 - 654
[2] Angew. Chem., 2013, vol. 125, # 2, p. 678 - 682,5
[3] Chinese Chemical Letters, 2018, vol. 29, # 10, p. 1497 - 1499
[4] Organic Letters, 2011, vol. 13, # 23, p. 6196 - 6199
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 24, p. 3954 - 3962

7-Hydroxy-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Hydroxy-1,2,3,4-tetrahydroquinoline manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
7-Hydroxy-1,2,3,4-tetrahydroquinoline 58196-33-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-08

58196-33-1, 7-Hydroxy-1,2,3,4-tetrahydroquinolineRelated Search:

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  • 7-Hydroxy-1,2,3,4-tetrahydroquinoline ISO 9001：2015 REACH
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  • Venadaparib Impurity 56
  • 58196-33-1