ChemicalBook > CAS DataBase List > CDK4/6-IN-2

CDK4/6-IN-2

Product Name
CDK4/6-IN-2
CAS No.
1800506-48-2
Chemical Name
CDK4/6-IN-2
Synonyms
AM24679P4;CDK4/6-IN-2;CDK4/6 inhibitor 2;Bireociclib (XZP-3287,CDK4/6-IN-2 );Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor;5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine;2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-
CBNumber
CB75419703
Molecular Formula
C27H32F2N8
Formula Weight
506.59
MOL File
1800506-48-2.mol
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CDK4/6-IN-2 Property

Boiling point:
665.2±65.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5.2 mg/mL (10.26 mM)
pka
7.67±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0083151
Product name
CDK4/6-IN-2
Purity
99.82%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0083151
Product name
CDK4/6-IN-2
Purity
99.82%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0083151
Product name
CDK4/6-IN-2
Purity
99.82%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0083151
Product name
CDK4/6-IN-2
Purity
99.82%
Packaging
100mg
Price
$2650
Updated
2021/12/16
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CDK4/6-IN-2 Chemical Properties,Usage,Production

Description

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. CDK4|2.7 nM (IC50)|CDK6|16 nM (IC50)

CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1].

Uses

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].

IC 50

CDK4: 2.7 nM (IC50); CDK6: 16 nM (IC50)

References

[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.

CDK4/6-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK4/6-IN-2 Suppliers

China 25 United States 3 Global 28
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4818
Advantage
55
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
8556
Advantage
58
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
597
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32469
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4998
Advantage
58
cjbscvictory
Tel
13348960310 13348960310;
Email
3003867561@qq.com
Country
China
ProdList
10501
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58

1800506-48-2, CDK4/6-IN-2Related Search:


  • CDK4/6-IN-2
  • CDK4/6 inhibitor 2
  • 5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine
  • AM24679P4
  • Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor
  • 2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-
  • Bireociclib (XZP-3287,CDK4/6-IN-2 )
  • 1800506-48-2
  • CHFN