1V209

Product Name: 1V209
CAS No.: 1062444-54-5
Chemical Name: 1V209
Synonyms: 1V209;TLR7 agonist T7;1V209, 10 mM in DMSO;1V209(TLR7 agonist T7);TLR7 agonist T7 (1V209);1V209 (TLR7 agonist T7) ，S0078;2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine;4-[[6-Amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9(8H)-yl]methyl]benzoic Acid;4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7，8-dihydro-9H-purin-9-yl)methyl)benzoic acid;Benzoic acid, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-
CBNumber: CB75583509
Molecular Formula: C16H17N5O5
Formula Weight: 359.34
MOL File: 1062444-54-5.mol

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1V209 Property

Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 83.33 mg/mL (231.90 mM)
form: Solid
pka: 4.23±0.10(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0085942
Product name: 1V209
Purity: 99.52%
Packaging: 5mg
Price: $115
Updated: 2021/12/16

ChemScene

Product number: CS-0085942
Product name: 1V209
Purity: 99.52%
Packaging: 10mg
Price: $195
Updated: 2021/12/16

ChemScene

Product number: CS-0085942
Product name: 1V209
Purity: 99.52%
Packaging: 25mg
Price: $410
Updated: 2021/12/16

ChemScene

Product number: CS-0085942
Product name: 1V209
Purity: 99.52%
Packaging: 50mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0085942
Product name: 1V209
Purity: 99.52%
Packaging: 100mg
Price: $1210
Updated: 2021/12/16

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1V209 Chemical Properties,Usage,Production

Uses

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity[1][2].

in vivo

The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration^[1].

IC 50

TLR7

References

[1] Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105. DOI:10.1002/adhm.201901105
[2] Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23. DOI:10.1021/acs.bioconjchem.5b00285

1V209 Preparation Products And Raw materials

Raw materials

Preparation Products

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1V209 Suppliers

China 51 United States 3 Global 54

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Shanghai GL Peptide Ltd.

Tel: +86-21-61263340; 17609490614 13764994101
Fax: 021-61263399
Email: fisherwang@glschina.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

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Email: 3193328036@qq.com
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Fan De(Beijing) Biotechnology Co., Ltd.

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Shanghai Jifeng Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Country: CHINA
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1062444-54-5, 1V209Related Search:

1V209

TLR7 agonist T7

Benzoic acid, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-

4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7，8-dihydro-9H-purin-9-yl)methyl)benzoic acid

1V209(TLR7 agonist T7)

TLR7 agonist T7 (1V209)

2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine

cell,polysaccharides,IP-10,intravenous,MCP-1,Tumor,1V-209,IL-6,1V209,Toll-like Receptor (TLR),conjugate,Inhibitor,cancer,TNFα,inhibit

4-[[6-Amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9(8H)-yl]methyl]benzoic Acid

1V209, 10 mM in DMSO

1V209 (TLR7 agonist T7) ，S0078

1062444-54-5