DVL2 antibody
Source Reactivity Background References- Product Name
- DVL2 antibody
- Chemical Name
- DVL2 antibody
- Synonyms
- DVL2 antibody;Rabbit Polyclonal DVL2 Antibody
- CBNumber
- CB75623601
- Formula Weight
- 0
- MOL File
- Mol file
DVL2 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Hamster;Monkey;Mink
Background
Dishevelled proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3β promoting β-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. There are three Dsh homologs, Dvl1, Dvl2 and Dvl3 in mammals. Upon treatment with Wnt proteins, Dvls become hyperphosphorylated and accumulate in the nucleus. Dvl proteins also associate with actin fibers and cytoplasmic vesicular membranes and mediate endocytosis of the Fzd receptor after Wnt protein stimulation. Overexpression of Dvl has been reported in certain cancers.
References
[1] Logan, C.Y. and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810.
[2] Boutros, M. and Mlodzik, M. (1999) Mech. Dev. 83, 27-37.
[3] Lee, J.S. et al. (1999) J. Biol. Chem. 274, 21464-70.
[4] Itoh, K. et al. (2005) J. Biol. 4, 3.1-3.12.
[5] Capelluto, D.G. et al. (2002) Nature 419, 726-729.
[6] Chen, W. et al. (2003) Science 301, 1391-1394.
[7] Okino , K. et al. (2003) Oncol. Rep. 10, 1219-1223.
[8] Uematsu, K. et al. (2003) Oncogene 22, 7218-7221.
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Raw materials
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