NDUFS1 antibody
Source Reactivity Background References- Product Name
- NDUFS1 antibody
- Chemical Name
- NDUFS1 antibody
- Synonyms
- NDUFS1 antibody
- CBNumber
- CB75665894
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb6486
- Product name
- Ndufs1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 5μg(Trial Size)
- Price
- $66.3
- Updated
- 2021/12/16
- Product number
- orb128425
- Product name
- NDUFS1 antibody
- Purity
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 25μg(Trial Size)
- Price
- $119
- Updated
- 2021/12/16
- Product number
- orb6486
- Product name
- Ndufs1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 20μg(Trial Size)
- Price
- $141.1
- Updated
- 2021/12/16
- Product number
- orb128425
- Product name
- NDUFS1 antibody
- Purity
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Packaging
- 100μg
- Price
- $272
- Updated
- 2021/12/16
- Product number
- orb135970
- Product name
- NDUFS1 antibody
- Purity
- Affinity purification
- Packaging
- 50μl
- Price
- $316.2
- Updated
- 2021/12/16
NDUFS1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
NDUFS1 is a nuclear encoded structural subunit of NADH: ubiquinone oxidoreductase (complex 1) in the mitochondrial electron transport chain. Mutations in NDUFS1 and other complex 1 subunits leading to mitochondrial dysfunction are associated with a number of neurological disorders. High-fat diet associated with type 2 diabetes leads to decreased expression of complex 1 subunits, including NDUFS1. NDUFS1 is the target of cleavage by apoptotic caspases contributing to the loss of mitochondrial transmembrane potential, compromised mitochondrial respiration, increased mitochondrial reactive oxygen species production, and loss of lysosomal integrity. NDUFS1 can also be cleaved by the lymphocyte protease granzyme B. Studies have also found that MDM2, which has a canonical role as an inhibitor of the tumor suppressor p53, can also sequester NDUFS1 in the cytoplasm, leading to respiratory dysfunction and increases in ROS.
References
[1] Duncan, A.M. et al. (1992) Cytogenet Cell Genet 60, 212-3.
[2] Petruzzella, V. et al. (2012) Adv Exp Med Biol 942, 371-84.
[3] Pagniez-Mammeri, H. et al. (2012) Mol Genet Metab 105, 163-72.
[4] Kashani, A. et al. (2014) Neurogenetics 15, 161-4.
[5] Zhu, Y. et al. (2015) J Hum Genet 60, 11-6.
[6] Sparks, L.M. et al. (2005) Diabetes 54, 1926-33.
[7] Ricci, J.E. et al. (2004) Cell 117, 773-86.
[8] Huai, J. et al. (2013) J Cell Sci 126, 4015-25.
[9] Dildine, S.L. and Semler, B.L. (1989) J Virol 63, 847-62.
[10] Elkholi, R. et al. (2019) Mol Cell 74, 452-465.e7.
NDUFS1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
NDUFS1 antibody Suppliers
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