PRAME antibody
Source Reactivity Background References- Product Name
- PRAME antibody
- Chemical Name
- PRAME antibody
- Synonyms
- PRAME antibody
- CBNumber
- CB75675817
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb100949
- Product name
- PRAME antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb100949
- Product name
- PRAME antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
PRAME antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
Cancer/testis antigens are a family of more than 100 proteins whose normal expression is largely restricted to immune privileged germ cells of the testis, ovary, and trophoblast cells of the placenta. Although most normal somatic tissues are void of CTA expression, due to epigenetic silencing of gene expression, their expression is upregulated in a wide variety of human solid and liquid tumors. As such, CTAs have garnered much attention as attractive targets for a variety of immunotherapy-based approaches to selectively attack tumors.PRAME is a cancer/testis antigen not normally expressed in any tissues except testis, but is upregulated in tumors. PRAME is expressed in melanoma cells and is recognized by cytolytic T-cells. It is also upregulated in other diseases, such as synovial sarcoma, NSCLC, and breast cancer, where it is thought to contribute to tumorigenesis and metastasis. PRAME is also highly expressed in liquid tumors such as AML and can be predictive of clinical outcome in some circumstances. PRAME and other cancer/testis antigens are currently being pursued as novel immunotherapy targets and diagnostic biomarkers.
References
[1] Caballero, O.L. and Chen, Y.T. (2009) Cancer Sci 100, 2014-21.
[2] De Smet, C. et al. (1999) Mol Cell Biol 19, 7327-35.
[3] Gjerstorff, M.F. et al. (2015) Oncotarget 6, 15772-87.
[4] Ikeda, H. et al. (1997) Immunity 6, 199-208.
[5] Iura, K. et al. (2017) Hum Pathol 61, 130-139.
[6] Gunn, R.B. and Fröhlich, O. (1989) Methods Enzymol 173, 54-80.
[7] Sun, Z. et al. (2016) Gene 594, 160-164.
[8] Qin, Y.Z. et al. (2017) Oncol Lett 13, 2823-2830.
[9] Oehler, V.G. et al. (2009) Blood 114, 3299-308.
[10] Salmaninejad, A. et al. (2016) Immunol Invest 45, 619-40.
PRAME antibody Preparation Products And Raw materials
Raw materials
Preparation Products
PRAME antibody Suppliers
- Tel
- 18007124176 19384116026
- 2706668885@qq.com
- Country
- China
- ProdList
- 4987
- Advantage
- 58
- Tel
- 027-87196173
- cusabio@163.com
- Country
- China
- ProdList
- 6066
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- ruihening88@163.com
- Country
- China
- ProdList
- 3009
- Advantage
- 58
- Tel
- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
- Advantage
- 58
- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6725
- Advantage
- 58
- Tel
- 4006-123-828 13162017139
- market@ab-mart.com
- Country
- China
- ProdList
- 6917
- Advantage
- 58
- Tel
- 025-58868422
- info@sabbiotech.com
- Country
- China
- ProdList
- 6243
- Advantage
- 58
- Tel
- 13047170542
- marketing@fn-test.com
- Country
- China
- ProdList
- 6600
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58