VEGF-C, human recombinant
- Product Name
- VEGF-C, human recombinant
- Chemical Name
- VEGF-C, human recombinant
- Synonyms
- VEGF-C, human recombinant
- CBNumber
- CB75761976
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- 32054
- Product name
- VEGF-C (human, recombinant)
- Packaging
- 5μg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 32054
- Product name
- VEGF-C (human, recombinant)
- Packaging
- 100μg
- Price
- $319
- Updated
- 2024/03/01
- Product number
- 32054
- Product name
- VEGF-C (human, recombinant)
- Packaging
- 1mg
- Price
- $1659
- Updated
- 2024/03/01
- Product number
- 32054
- Product name
- VEGF-C (human, recombinant)
- Packaging
- 50μg
- Price
- $200
- Updated
- 2021/12/16
VEGF-C, human recombinant Chemical Properties,Usage,Production
Description
VEGF-C is a member of the PDGF/VEGF family of growth factors that promotes lymphangiogenesis.1 VEGF-C exists as a secreted homodimer composed of a central VEGF homology domain that contains the receptor binding region and is flanked by N- and C-terminal propeptides, which are proteolytically cleaved by furin and ADAMTS3 or plasmin to generate the mature, active protein.2,3 VEGF-C is produced by macrophages, fibroblasts, smooth muscle cells, and tumor cells.3 VEGFC expression is upregulated by stimulation with IL-1β, TNF-α (Item Nos. 32020 | 32069), PDGF, TGF-β, or EGF (Item Nos. 32057 | 32025) and downregulated by dexamethasone (Item No. 11015).4,3 Binding of VEGF-C to its receptors, VEGFR2 and VEGFR3, which are expressed by endothelial cells, stimulates the migration, proliferation, and survival of endothelial cells and increases vascular permeability.3 VEGF-C induces angiogenesis in chick embryo chorioallantoic membranes and stimulates proliferation and migration of porcine aortic endothelial cells in vitro.5 Genome-wide deletion of Vegfc in mice induces embryonic edema and defects in lymphatic vascular development and is perinatal lethal.6 Increased VEGF-C tumor levels are positively correlated with poor prognosis, decreased overall survival, and resistance to hormone therapy in patients with breast cancer.7 VEGFC SNPs have been found in patients with non-small cell lung cancer (NSCLC), as well as colorectal or prostate cancer. Cayman's VEGF-C (human, recombinant) protein can be used for binding and cell-based assay applications. This protein consists of 136 amino acids, has a calculated molecular weight of 15.5 kDa, and a predicted N-terminus of Thr103 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 22 to 24 kDa due to glycosylation.WARNING This product is not for human or veterinary use.
VEGF-C, human recombinant Preparation Products And Raw materials
Raw materials
Preparation Products
VEGF-C, human recombinant Suppliers
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 13675144456
- alan.chow@synzest.com
- Country
- China
- ProdList
- 9470
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- 58
- Tel
- 800-364-9897
- sales@caymanchem.com
- Country
- China
- ProdList
- 6838
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 14748676110
- Country
- CHINA
- ProdList
- 112
- Advantage
- 58