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VTP50469

Product Name
VTP50469
CAS No.
2169916-18-9
Chemical Name
VTP50469
Synonyms
VTP50469;VTP50469, 10 mM in DMSO;5-Fluoro-N,N-diisopropyl-2-((4-(7-((trans-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide;Benzamide, 5-fluoro-N,N-bis(1-methylethyl)-2-[[4-[7-[[trans-4-[(methylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-;Menin-MLL,leukemia,survival,VTP 50469,Epigenetic Reader Domain,antiproliferative,Apoptosis,Inhibitor,protein-protein,VTP-50469,inhibit,VTP50469,differentiation
CBNumber
CB75839891
Molecular Formula
C32H47FN6O4S
Formula Weight
630.82
MOL File
2169916-18-9.mol
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VTP50469 Property

Boiling point:
735.2±70.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
solubility 
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
form 
Solid
pka
10.97±0.40(Predicted)
color 
White to light yellow
InChIKey
ADHHOUXZPBYYSU-YOCNBXQISA-N
SMILES
C(N(C(C)C)C(C)C)(=O)C1=CC(F)=CC=C1OC1=CN=CN=C1N1CC2(CCN(C[C@@H]3CC[C@@H](NS(C)(=O)=O)CC3)CC2)C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0077527
Product name
VTP50469
Purity
99.41%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0077527
Product name
VTP50469
Purity
99.41%
Packaging
10mg
Price
$780
Updated
2021/12/16
ChemScene
Product number
CS-0077527
Product name
VTP50469
Purity
99.41%
Packaging
50mg
Price
$2150
Updated
2021/12/16
ChemScene
Product number
CS-0077527
Product name
VTP50469
Purity
99.41%
Packaging
100mg
Price
$2850
Updated
2021/12/16
DC Chemicals
Product number
012382
Product name
VTP50469
Packaging
003
Price
$3600
Updated
2021/12/16
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VTP50469 Chemical Properties,Usage,Production

Uses

VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity[1][2].

in vivo

VTP50469 (15-60 mg/kg; oral administration; twice a day; for 28 days; NSG mice) treatment is highly efficacious across all dosage levels and all treatment groups have a significant survival advantage. Mice dosed at 30 and 60 mg/kg VTP50469 extends survival advantage[1].

Animal Model:Unconditioned immunodeficient (NSG) mice with MV4;11 cells[1]
Dosage:15 mg/kg, 30 mg/kg, and 60 mg/kg
Administration:Oral administration; twice a day; for 28 days
Result:Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.

References

[1] Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11. DOI:10.1016/j.ccell.2019.11.001

[2] Andrei V. Krivtsov, et al. Abstract 4958: VTP50469 is a novel, orally available menin-MLL1 inhibitor effective against MLL-rearranged and NPM1-mutant leukemia. Cancer Resceach. July 2018.Volume 78, Issue 13 Supplement.

VTP50469 Preparation Products And Raw materials

Raw materials

Preparation Products

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VTP50469 Suppliers

China 45 United States 3 Global 48
Zhengzhou Haode Pharmaceutical Technology Co.,Ltd
Tel
18037386321
Email
3330511471@qq.com
Country
China
ProdList
500
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
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58
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2389
Advantage
58
Shanghai Changyu Medical Technology Co. Ltd.
Tel
+86-13301875428
Email
sales@changyuhe.com
Country
China
ProdList
311
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58

2169916-18-9, VTP50469Related Search:


  • VTP50469
  • Benzamide, 5-fluoro-N,N-bis(1-methylethyl)-2-[[4-[7-[[trans-4-[(methylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-
  • Menin-MLL,leukemia,survival,VTP 50469,Epigenetic Reader Domain,antiproliferative,Apoptosis,Inhibitor,protein-protein,VTP-50469,inhibit,VTP50469,differentiation
  • 5-Fluoro-N,N-diisopropyl-2-((4-(7-((trans-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide
  • VTP50469, 10 mM in DMSO
  • 2169916-18-9
  • 2169919-18-9