N-Mal-N-bis(PEG2-NHS ester)
- Product Name
- N-Mal-N-bis(PEG2-NHS ester)
- CAS No.
- 2182601-73-4
- Chemical Name
- N-Mal-N-bis(PEG2-NHS ester)
- Synonyms
- N-Mal-N-bis(PEG2-NHS ester);N-Mal-N-bis(PEG2-CH2CH2COONHS);4,7,13,16-Tetraoxa-10-azanonadecanedioic acid, 10-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,19-bis(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber
- CB75852010
- Molecular Formula
- C29H38N4O15
- Formula Weight
- 682.63
- MOL File
- 2182601-73-4.mol
N-Mal-N-bis(PEG2-NHS ester) Property
- Boiling point:
- 810.4±75.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light, stored under nitrogen
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- -0.93±0.70(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23777
- Product name
- N-Mal-N-bis(PEG2-NHSester)
- Purity
- 95%
- Packaging
- 100mg
- Price
- $790
- Updated
- 2021/12/16
N-Mal-N-bis(PEG2-NHS ester) Chemical Properties,Usage,Production
Description
N-Mal-N-bis(PEG2-NHS ester) is an maleimide NHS esters. The NHS esters can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Uses
N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-Mal-N-bis(PEG2-NHS ester) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Mal-N-bis(PEG2-NHS ester) manufacturers
- Product
- N-Mal-N-bis(PEG2-NHS ester) 2182601-73-4
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-28