Mobocertinib succinate
- Product Name
- Mobocertinib succinate
- CAS No.
- 2389149-74-8
- Chemical Name
- Mobocertinib succinate
- Synonyms
- TAK788 succinate;788Succinic acid;AP32788 succinate;Mopotinib succinate;TAK-788 Succinic acid;Mobocertinib succinate;Mobocertinib succinate（TAK788）;obocertinib Succinate (TAK-788 Succinate);Mobocertinib Succinate (TAK-788 Succinate);isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate succinate
- CBNumber
- CB76183654
- Molecular Formula
- C36H45N7O8
- Formula Weight
- 703.8
- MOL File
- 2389149-74-8.mol
Mobocertinib succinate Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (35.52 mM; Need ultrasonic)
- InChI
- InChI=1S/C32H39N7O4.C4H6O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26;5-3(6)1-2-4(7)8/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36);1-2H2,(H,5,6)(H,7,8)
- InChIKey
- YXYAEUMTJQGKHS-UHFFFAOYSA-N
- SMILES
- C(C(=O)O)CC(=O)O.C(C1=CN=C(NC2C=C(NC(=O)C=C)C(N(C)CCN(C)C)=CC=2OC)N=C1C1=CN(C)C2=CC=CC=C12)(=O)OC(C)C
N-Bromosuccinimide Price
- Product number
- CS-0114257
- Product name
- Mobocertinib(succinate)
- Purity
- 99.61%
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0114257
- Product name
- Mobocertinib(succinate)
- Purity
- 99.61%
- Packaging
- 25mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0114257
- Product name
- Mobocertinib(succinate)
- Purity
- 99.61%
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0114257
- Product name
- Mobocertinib(succinate)
- Purity
- 99.61%
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0114257
- Product name
- Mobocertinib(succinate)
- Purity
- 99.61%
- Packaging
- 500mg
- Price
- $950
- Updated
- 2021/12/16
Mobocertinib succinate Chemical Properties,Usage,Production
Description
Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research.
Uses
Mobocertinib is an oral targeted therapy drug[1].Mobocertinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that cannot be removed by surgery and has spread to other parts of the body either during or after treatment with platinum chemotherapy medications.
Mechanism of action
Mobocertinib acts to inhibit EGFR exon 20 insertion mutations at a lower concentration than it does on wild-type proteins.
Side effects
Diarrhoea, rash, nausea, stomatitis, vomiting, decreased appetite, paronychia, fatigue, dry skin,musculoskeletal pain, increased amylase/lipase/creatinine, and decreased potassium/hemoglobin/magnesium/lymphocytes.
Synthesis
Mobocertinib succinate is prepared by the reaction of Isopropyl 2-chloro-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate in the presence of an inert atmosphere.
References
[1] IMRANMOHD. Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions.[J]. Biomedicines, 2021. DOI:10.3390/biomedicines9121938.
Mobocertinib succinate Preparation Products And Raw materials
Raw materials
Preparation Products
Mobocertinib succinate Suppliers
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52927
- Advantage
- 58
View Lastest Price from Mobocertinib succinate manufacturers
- Product
- 788Succinic acid 2389149-74-8
- Price
- US $90.00-900.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30
- Product
- Mobocertinib succinate 2389149-74-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ＞99.5% by HPLC
- Supply Ability
- 100kg/month
- Release date
- 2023-02-18
- Product
- Mopotinib succinate 2389149-74-8
- Price
- US $10.00/g
- Min. Order
- 0.0010000000474974513g
- Purity
- >99%
- Supply Ability
- No upper limit
- Release date
- 2022-10-26