ChemicalBook > CAS DataBase List > PF-06256142
PF-06256142
- Product Name
- PF-06256142
- CAS No.
- 1609583-14-3
- Chemical Name
- PF-06256142
- Synonyms
- PF-06256142;PF 06256142,PF06256142;Imidazo[1,2-a]pyrazine, 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methyl-, (5S)-
- CBNumber
- CB76226308
- Molecular Formula
- C21H16N4O2
- Formula Weight
- 356.38
- MOL File
- 1609583-14-3.mol
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PF-06256142 Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 200 mg/mL (514.88 mM; Need ultrasonic)
- pka
- 4.68±0.40(Predicted)
- form
- Solid
- color
- White to off-white
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PF-06256142 Chemical Properties,Usage,Production
Biological Activity
PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease[1]. PF-06256142 exhibits IC50 values of 10 μM)[1]. PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg)[1].PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg)[1].
References
[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15.
PF-06256142 Preparation Products And Raw materials
Raw materials
Preparation Products
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PF-06256142 Suppliers
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