Antide

Description

Product Name: Antide
CAS No.: 112568-12-4
Chemical Name: Antide
Synonyms: Antide Acetate;lyl-;ANTIDE;iturelix;Orf 23541;Brn 4866881;Antide impurity;ANTIDE (iturelix);Iturelix, ORF 23541;Antide >=97% (HPLC)
CBNumber: CB7665086
Molecular Formula: C82H108ClN17O14
Formula Weight: 1591.29
MOL File: 112568-12-4.mol

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Antide Property

Boiling point:: 1798.0±65.0 °C(Predicted)
Density: 1.258±0.06 g/cm3(Predicted)
storage temp.: −20°C
form: Solid
pka: 12.78±0.46(Predicted)
color: White to off-white
InChI: InChI=1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+/m1/s1
InChIKey: QRYFGTULTGLGHU-NBERXCRTSA-N
SMILES: C(N)(=O)[C@@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(C1=CC=CN=C1)=O)NC(=O)[C@H](CCCCNC(C1=CC=CN=C1)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CC=CN=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(C)=O

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Safety

Hazard Codes: T
Risk Statements: 60
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: AY2961700
HS Code: 3504009000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8802
Product name: Antide
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $198
Updated: 2022/05/15

Usbiological

Product number: A2298-09T
Product name: Antide
Packaging: 1mg
Price: $368
Updated: 2021/12/16

Usbiological

Product number: 169600
Product name: Antide Acetate
Packaging: 1mg
Price: $549
Updated: 2021/12/16

TRC

Product number: A637190
Product name: Antide
Packaging: 1mg
Price: $140
Updated: 2021/12/16

TRC

Product number: A637190
Product name: Antide
Packaging: 10mg
Price: $910
Updated: 2021/12/16

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Antide Chemical Properties,Usage,Production

Uses

Reversible inhibition of gonadotropin secretion and subsequent suppression of ovarian and testicular steroid secretio (gonadotropin releasing hormone antagonist).

Uses

Antide, is a GnRH and LH-RH antagonist, and with high anti-ovulatory and negligible histamine release activity.

in vivo

Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys^[1].

Animal Model:	Cynomolgus monkey and rat^[1]
Dosage:	1, 3, 6, 10 and 15 mg/kg
Administration:	Subcutaneous, once or on 5 consecutive days
Result:	Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.

Description

Antide acetate (Ac-AA10-NH₂) is an LHRH antagonist and represses LH and FSH release from the pituitary gland. Antide Mw is 1590.6 Dalton.

Antide Preparation Products And Raw materials

Raw materials

Preparation Products

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Antide Suppliers

China 161 Japan 1 South Korea 1 Switzerland 1 United Kingdom 6 United States 20 Global 190

Adachibio Inc.

Tel: +81-8027837258; +8108027837258
Fax: 0081-80278372055
Email: sales@adachibio.com
Country: Japan
ProdList: 992
Advantage: 58

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View Lastest Price from Antide manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Antide 112568-12-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Antide 112568-12-4
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-01

Hubei Harvest Chemical CO.,Ltd

Product: Antide 112568-12-4
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 100000000000
Release date: 2022-12-27

112568-12-4, AntideRelated Search:

L-Leucinamide hydrochloride 3-Pyridineethaneamine L-Serinamide hydrochloride (2R)-2-Aminopropanamide hydrochloride Antide H-ALA-ALA-ALA-NH2 HCL 3-NAPHTHALEN-2-YL-PROPIONALDEHYDE H-GLY-LEU-NH2 HCL H-D-PHE-NH2 HCL AC-LYS-NH2 HCL 1-METHYL-2-PYRIDIN-4-YL-ETHYLAMINE (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97% 1-(N-ACETYLAMINO)-2-(4-CHLOROPHENYL)-ETHANE H-NLE-NH2 HCL 2-AMINO-1-PYRROLIDIN-1-YL-ETHANONE HCL p-Chloroamphetamine DL-NORLEUCINE AMIDE HYDROCHLORIDE H-PRO-GLY-NH2 HCL

iturelix

Ac-D-2-Nal-4-chloro-D-Phe-beta-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2

AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2

Brn 4866881

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N(sup 6)-(3-pyridinylcarbonyl)-L-lysyl-N(sup 6)-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N(sup 6)-(1-methylethyl)-L-lysyl-L-prolyl-

D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N6-(3-pyridinylcarbonyl)-L-lysyl-N6-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-

Orf 23541

Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2

Iturelix, ORF 23541

Ac-D-2-Nal-p-chloro-D-Phe-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl) -D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2

ANTIDE (iturelix)

Antide, Iturelix, ORF 23541

Antide Acetate, Iturelix

-(3-pyridinylcarbonyl)-d-lysyl-l-leucyl-n(sup6)-(1-methylethyl)-l-lysyl-l-pro

3-pyridinyl)-d-alanyl-l-seryl-n(sup6)-(3-pyridinylcarbonyl)-l-lysyl-n(sup6)

lyl-

ANTIDE

AC-(D-NAL)-(D-P-CL-PHE)-(D-PAL)-SER-LYS(NICOTINOYL)-[D-LYS(NICOTINOYL)]-LEU-LYS(ISOPROPYL)-PRO-[D-ALA]-NH2

AC-D-ALA(2-NAPHTHYL)-D-PHE(4-CL)-D-ALA(3'-PYRIDYL)-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2

AC-D-2-NAL-P-CHLORO-D-PHE-BETA-(3-PYRIDYL)-D-ALA-SER-LYS(NICOTINOYL)-D-LYS(NICOTINOYL)-LEU-LYS(ISOPROPYL)-PRO-D-ALA-NH2

Antide Acetate

Ac-D-2-Nal-p-chloro-D-Phe-.beta.-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2

Antide >=97% (HPLC)

Antide impurity

Peptides Antide Acetate

N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-amino-1-oxopropan-2-yl)carbamoyl)pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotinamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)nicotinamide

N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-(((R)-1-Amino-1-oxo-propan-2-yl)-carbamoyl)-pyrrolidin-1-yl)-6-(isopropylamino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamoyl)-7-(4-chlorobenzyl)-13-(hydroxymethyl)-4-(naphthalen-2-ylmethyl)-16-(4-(nicotincarboxcarboxcarboxamido)butyl)-2,5,8,11,14,17-hexaoxo-10-(pyridin-3-ylmethyl)-3,6,9,12,15,18-hexaazatricosan-23-yl)-pyridin-3-carboxamide

112568-12-4

C82H108ClN17O14

LH-RH

Peptides

Releasing Factors

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

hormones

Peptide

LH-RH

LH-RHPeptides for Cell Biology

Neuropeptides

Releasing Factors