3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

Product Name: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
CAS No.: 1135-23-5
Chemical Name: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
Synonyms: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID;HYDROFERULIC ACID;Shorbic Acid;Dihydroconiferylic Acid;HYDROFERULIC ACID(RG);3-Methoxyphloretic Acid;Ferulic Acid Impurity 1;3-(4-HYDROXYMETHYL)PROPIONIC ACID;Dihydroferulic acid, 10 mM in DMSO;Pyridoxal 5'-phosphate hydrate(1:x)
CBNumber: CB7665965
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 1135-23-5.mol

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3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Property

Melting point:: 87-93 °C
Boiling point:: 120-130 °C(Press: 0.5 Torr)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in dimethyl sulfoxide and methanol.
pka: 4.73±0.10(Predicted)
form: powder to crystal
color: White to Light yellow
BRN: 2110370
InChI: InChI=1S/C10H12O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2,4,6,11H,3,5H2,1H3,(H,12,13)
InChIKey: BOLQJTPHPSDZHR-UHFFFAOYSA-N
SMILES: C1(CCC(O)=O)=CC=C(O)C(OC)=C1
LogP: 0.810 (est)
CAS DataBase Reference: 1135-23-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 17803
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic acid
Purity: ≥96.0% (T)
Packaging: 5g
Price: $219
Updated: 2025/07/31

TCI Chemical

Product number: H1180
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
Purity: >98.0%(GC)
Packaging: 1g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: H1180
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
Purity: >98.0%(GC)
Packaging: 5g
Price: $199
Updated: 2025/07/31

TRC

Product number: D448900
Product name: DihydroFerulicAcid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR925053
Product name: 4-Hydroxy-3-methoxy-benzenepropanoic acid
Packaging: 1g
Price: $131
Updated: 2021/12/16

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3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production

Uses

3-(4-Hydroxy-3-methoxyphenyl)propionic acid (hydroferulic acid) was used to inhibit prostaglandin E(2) production.

Uses

A caffeine metabolite which showed high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.

Definition

ChEBI: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 3 has been replaced by a 4-hydroxy-3-methoxyphenyl group.

Synthesis

1135-24-6

1135-23-5

The general procedure for the synthesis of isopropyl phosphate (mono- and di-ester mixtures) from 3-methoxy-4-hydroxyphenylacrylic acid was as follows: to a stirred suspension of ferulic acid (25 g, 128.74 mmol) in methanol (200 ml) was added Pd/C catalyst (3.75 g). The reaction mixture was subjected to hydrogenation under hydrogen pressure of 1.2 MPa for 4 h at 50°C. Upon completion of the reaction, the mixture was cooled to room temperature, the catalyst was removed by filtration, and a white solid product (25 g, 99% yield) was obtained by concentration under reduced pressure. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and ESI-MS: 1H NMR δ 6.76 (d, J = 7.8 Hz, 1H), 6.62 (m, 2H), 3.79 (s, 3H), 2.81 (t, J = 7.7 Hz, 2H), 2.58 (t, J = 7.7 Hz, 2H); ESI-MS m /z: 195.1 [M-H]?

in vivo

Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats^[4].

References

[1] Advanced Synthesis and Catalysis, 2013, vol. 355, # 1, p. 81 - 86
[2] Tetrahedron Letters, 2010, vol. 51, # 44, p. 5753 - 5756
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4462 - 4466
[4] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 429 - 439
[5] Journal of the American Chemical Society, 2017, vol. 139, # 10, p. 3767 - 3773

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Suppliers

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View Lastest Price from 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(4-Hydroxy-3-Methoxyphenyl)propionic acid 135-23-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-01-20

Shanghai Standard Technology Co., Ltd.

Product: 3-(4-Hydroxy-3-Methoxyphenyl)Propionic Acid 1135-23-5
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-25

1135-23-5, 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACIDRelated Search:

Hexacosyl (E)-ferulate 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE 2-Propenoic acid, 3-[4-(acetyloxy)-3-methoxyphenyl]-, 2-acetyl-5-methoxyphenyl ester (E)-3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid ethyl ester 3-Feruloyl-1-Sinapoyl sucrose Methyl 3-(4-Hydroxy-3-methoxyphenyl)propionate Isopropyl ferulate CINNAMYLISOFERULATE 4-hydroxy-5-methoxyisophthalaldehyde SODIUM ISOFERULATE No Coniferyl alcohol 3-(4-HYDROXY-3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CIS-FERULICACID 3-(4-HYDROXY-3-METHOXY-PHENYL)-2-METHYL-ACRYLIC ACID trans-4-Acetoxy-3-methoxycinnamic acid Ferulic Acid Impurity 19 N-(4-AMINOBUTYL)-3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLAMIDE

3-(3-METHOXY-4-HYDROXYPHENYL)-PROPIONIC ACID

Benzenepropanoic acid, 4-hydroxy-3-methoxy-

3-Methoxyphloretic Acid

Dihydroconiferylic Acid

Shorbic Acid

β-3-Methoxy-4-hydroxyphenylpropionic acid

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID 98%

3-(4-Hydroxy-3-methoxyphenyl)propionic acid >=96.0% (T)

4-HYDROXY-3-METHOXYHYDROCINNAMIC ACID

3-METHOXY-4-HYDROXYHYDROCINNAMIC ACID

3-(4-HYDROXYMETHYL)PROPIONIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

BETA-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

HYDROFERULIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC

HYDROFERULIC ACID(RG)

3-Methoxy-4-hydroxybenzenepropanoic acid

3-Methoxy-4-hydroxybenzenepropionic acid

4-Hydroxy-3-methoxybenzenepropanoic acid

3-(4-hydroxy-3-methoxyphenyl)propanoate

3-(4-Hydroxy-3-methoxyphenyl)propionicAcid&gt

Ferulic Acid Impurity 1

Pyridoxal 5'-phosphate hydrate(1:x)

3-(4-Hydroxy-3-methoxyphenyl)propionic Acid, ≥ 96.0%

Dihydroferulic acid, 10 mM in DMSO

1135-23-5

135-23-5

HOCH3OC6H3CH2CH2CO

Organic Building Blocks

Building Blocks

Carboxylic Acids

C10

Carbonyl Compounds

standard material,plant extracts

Inhibitors

Aromatics, Metabolites & Impurities

Aromatic Cinnamic Acids, Esters and Derivatives

Aromatics

Metabolites & Impurities