2-ACETYLAMINO-ISONICOTINIC ACID

Product Name: 2-ACETYLAMINO-ISONICOTINIC ACID
CAS No.: 54221-95-3
Chemical Name: 2-ACETYLAMINO-ISONICOTINIC ACID
Synonyms: Zinc02559887;2-AcetylaMino-isonic acid;2-ACETAMIDOISONICOTINIC ACID;2-Acetylaminoisonicotinicaci;2-ACETYLAMINO-ISONICOTINIC ACID;2-acetamido-4-pyridinecarboxylate;2-(Acetylamino)isonicotinicacid97%;2-(Acetylamino)isonicotinic acid 97%;2-Acetamidopyridin-4-carboxylic acid;2-acetaMidopyridine-4-carboxylic acid
CBNumber: CB7666548
Molecular Formula: C8H8N2O3
Formula Weight: 180.16
MOL File: 54221-95-3.mol

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2-ACETYLAMINO-ISONICOTINIC ACID Property

Melting point:: 286-290
Boiling point:: 585.3±35.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: 1.74±0.10(Predicted)
Appearance: White to light yellow Solid

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Safety

Hazard Codes: Xi
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000361
Product name: 2-Acetylamino-isonicotinic acid
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: A168120
Product name: 2-Acetylamino-isonicotinic acid
Packaging: 5g
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-W017216
Product name: 2-Acetylamino-isonicotinic acid
Packaging: 25g
Price: $443
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020092
Product name: 2-ACETYLAMINOISONICOTINIC ACID
Purity: 95.00%
Packaging: 250MG
Price: $592.05
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020092
Product name: 2-ACETYLAMINOISONICOTINIC ACID
Purity: 95.00%
Packaging: 1G
Price: $615.34
Updated: 2021/12/16

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2-ACETYLAMINO-ISONICOTINIC ACID Chemical Properties,Usage,Production

Uses

2-Acetylaminoisonicotinic Acid is a reactant in the preparation of nicotinic acid analogues as potent-hypoxia inducible factor (HIF)-1α inhibitors.

Synthesis

5327-32-2

54221-95-3

b) Synthesis of 2-acetamido pyridine-4-carboxylic acid (3): 214.0 g of 2-(acetamido)-4-methylpyridine (2) was added in batches to an aqueous solution of 160 g of potassium permanganate at 50 °C while maintaining stirring. An additional 360 g of potassium permanganate was added in batches over a period of 1 hour, during which the temperature of the reaction mixture needed to be controlled not to exceed 90 °C. After completion of the reaction, stirring was continued for 1.5 hours, followed by thermal filtration. The pH of the filtrate was adjusted to 3-4 with concentrated hydrochloric acid, and the white precipitate precipitated was 2-acetylaminopyridine-4-carboxylic acid (3). After separation by filtration and drying under vacuum conditions, 108.0 g of product was obtained in 42% yield.

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4527 - 4530
[2] Patent: WO2006/89798, 2006, A1. Location in patent: Page/Page column 25
[3] Patent: EP1894925, 2008, A1. Location in patent: Page/Page column 14; 41
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 6942 - 6990
[5] Farmaco, Edizione Scientifica, 1958, vol. 13, p. 485,487

2-ACETYLAMINO-ISONICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ACETYLAMINO-ISONICOTINIC ACID Suppliers

China 79 France 1 India 1 The Netherlands 1 United Kingdom 1 United States 12 Global 95

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View Lastest Price from 2-ACETYLAMINO-ISONICOTINIC ACID manufacturers

Career Henan Chemical Co

Product: 2-ACETYLAMINO-ISONICOTINIC ACID 54221-95-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

54221-95-3, 2-ACETYLAMINO-ISONICOTINIC ACIDRelated Search:

ACETYL TETRAPEPTIDE-2 Ethanone, 1-(3,4-dihydro-2H-pyrrol-5-yl)- (9CI) 2-Aminoisonicotinic acid 3-(ACETYLAMINO)ISONICOTINIC ACID 2-ACETAMIDO-5-BROMOISONICOTINIC ACID 2-ACETYLAMINO-ISONICOTINIC ACID 2-(2,5-Dioxo-1-pyrrolidinyl)-4-pyridinecarboxylicacidethylester 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID

2-ACETYLAMINO-ISONICOTINIC ACID

2-AECTAMIDO-4-PYRIDINECARBOXYLIC ACID

2-ACETAMIDOISONICOTINIC ACID

2-(Acetylamino)isonicotinic acid 97%

2-Acetamido-4-pyridinecarboxylic acid

2-AcetylaMino-isonic acid

Zinc02559887

2-acetaMidopyridine-4-carboxylic acid

2-(Acetylamino)pyridine-4-carboxylic acid

2-(Acetylamino)isonicotinicacid97%

2-acetamido-4-pyridinecarboxylate

4-Pyridinecarboxylic acid, 2-(acetylamino)-

2-(Acetcarboxamido)-pyridin-4-carboxylic acid

2-Acetylaminoisonicotinicaci

2-Acetamidopyridin-4-carboxylic acid

54221-95-3

Amines

blocks

Carboxes

Pyridines