ChemicalBook > CAS DataBase List > 2-ACETYLAMINO-ISONICOTINIC ACID

2-ACETYLAMINO-ISONICOTINIC ACID

Product Name
2-ACETYLAMINO-ISONICOTINIC ACID
CAS No.
54221-95-3
Chemical Name
2-ACETYLAMINO-ISONICOTINIC ACID
Synonyms
Zinc02559887;2-AcetylaMino-isonic acid;2-ACETAMIDOISONICOTINIC ACID;2-Acetylaminoisonicotinicaci;2-ACETYLAMINO-ISONICOTINIC ACID;2-acetamido-4-pyridinecarboxylate;2-(Acetylamino)isonicotinicacid97%;2-(Acetylamino)isonicotinic acid 97%;2-Acetamidopyridin-4-carboxylic acid;2-acetaMidopyridine-4-carboxylic acid
CBNumber
CB7666548
Molecular Formula
C8H8N2O3
Formula Weight
180.16
MOL File
54221-95-3.mol
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2-ACETYLAMINO-ISONICOTINIC ACID Property

Melting point:
286-290
Boiling point:
585.3±35.0 °C(Predicted)
Density 
1.404±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
pka
1.74±0.10(Predicted)
Appearance
White to light yellow Solid
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000361
Product name
2-Acetylamino-isonicotinic acid
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
A168120
Product name
2-Acetylamino-isonicotinic acid
Packaging
5g
Price
$140
Updated
2021/12/16
ChemScene
Product number
CS-W017216
Product name
2-Acetylamino-isonicotinic acid
Packaging
25g
Price
$443
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020092
Product name
2-ACETYLAMINOISONICOTINIC ACID
Purity
95.00%
Packaging
250MG
Price
$592.05
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020092
Product name
2-ACETYLAMINOISONICOTINIC ACID
Purity
95.00%
Packaging
1G
Price
$615.34
Updated
2021/12/16
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2-ACETYLAMINO-ISONICOTINIC ACID Chemical Properties,Usage,Production

Uses

2-Acetylaminoisonicotinic Acid is a reactant in the preparation of nicotinic acid analogues as potent-hypoxia inducible factor (HIF)-1α inhibitors.

Synthesis

5327-32-2

54221-95-3

b) Synthesis of 2-acetamido pyridine-4-carboxylic acid (3): 214.0 g of 2-(acetamido)-4-methylpyridine (2) was added in batches to an aqueous solution of 160 g of potassium permanganate at 50 °C while maintaining stirring. An additional 360 g of potassium permanganate was added in batches over a period of 1 hour, during which the temperature of the reaction mixture needed to be controlled not to exceed 90 °C. After completion of the reaction, stirring was continued for 1.5 hours, followed by thermal filtration. The pH of the filtrate was adjusted to 3-4 with concentrated hydrochloric acid, and the white precipitate precipitated was 2-acetylaminopyridine-4-carboxylic acid (3). After separation by filtration and drying under vacuum conditions, 108.0 g of product was obtained in 42% yield.

References

[1] Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4527 - 4530
[2] Patent: WO2006/89798, 2006, A1. Location in patent: Page/Page column 25
[3] Patent: EP1894925, 2008, A1. Location in patent: Page/Page column 14; 41
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 6942 - 6990
[5] Farmaco, Edizione Scientifica, 1958, vol. 13, p. 485,487

2-ACETYLAMINO-ISONICOTINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ACETYLAMINO-ISONICOTINIC ACID Suppliers

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View Lastest Price from 2-ACETYLAMINO-ISONICOTINIC ACID manufacturers

Career Henan Chemical Co
Product
2-ACETYLAMINO-ISONICOTINIC ACID 54221-95-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

54221-95-3, 2-ACETYLAMINO-ISONICOTINIC ACIDRelated Search:

ACETYL TETRAPEPTIDE-2 Ethanone, 1-(3,4-dihydro-2H-pyrrol-5-yl)- (9CI) 2-Aminoisonicotinic acid 3-(ACETYLAMINO)ISONICOTINIC ACID 2-ACETAMIDO-5-BROMOISONICOTINIC ACID 2-ACETYLAMINO-ISONICOTINIC ACID 2-(2,5-Dioxo-1-pyrrolidinyl)-4-pyridinecarboxylicacidethylester 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID METHYL ESTER 2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID

  • 2-ACETYLAMINO-ISONICOTINIC ACID
  • 2-AECTAMIDO-4-PYRIDINECARBOXYLIC ACID
  • 2-ACETAMIDOISONICOTINIC ACID
  • 2-(Acetylamino)isonicotinic acid 97%
  • 2-Acetamido-4-pyridinecarboxylic acid
  • 2-AcetylaMino-isonic acid
  • Zinc02559887
  • 2-acetaMidopyridine-4-carboxylic acid
  • 2-(Acetylamino)pyridine-4-carboxylic acid
  • 2-(Acetylamino)isonicotinicacid97%
  • 2-acetamido-4-pyridinecarboxylate
  • 4-Pyridinecarboxylic acid, 2-(acetylamino)-
  • 2-(Acetcarboxamido)-pyridin-4-carboxylic acid
  • 2-Acetylaminoisonicotinicaci
  • 2-Acetamidopyridin-4-carboxylic acid
  • 54221-95-3
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