5-BROMO-1H-BENZIMIDAZOLE-2-AMINE
- Product Name
- 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE
- CAS No.
- 791595-74-9
- Chemical Name
- 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE
- Synonyms
- 2-Amino-5-bromobenzimidazole;2-amino-6-bromo benzimidazole;6-bromo-1H-Benzimidazol-2-amine;5-Bromo-1H-benzimidazol-2-amine;5-BROMO-1H-BENZIMIDAZOLE-2-AMINE;2-AMino-5-BroMo-1H-BenziMidazole;2-Amino-6-Bromo-1H-benzimidaZole;1H-Benzimidazol-2-amine, 6-bromo-;6-bromo-1H-1,3-benzodiazol-2-amine;2-AMINO-5(6)-BROMO-1H-BENZIMIDAZOLE
- CBNumber
- CB7667181
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- 791595-74-9.mol
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE Property
- Boiling point:
- 425.2±37.0 °C(Predicted)
- Density
- 1.867±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 10.16±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- X5385
- Product name
- 2-Amino-5-bromobenzimidazole
- Packaging
- 100mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- FB139452
- Product name
- 5-Bromo-1H-benzo[d]imidazol-2-amine
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FB139452
- Product name
- 5-Bromo-1H-benzo[d]imidazol-2-amine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB139452
- Product name
- 5-Bromo-1H-benzo[d]imidazol-2-amine
- Packaging
- 2g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- FB139452
- Product name
- 5-Bromo-1H-benzo[d]imidazol-2-amine
- Packaging
- 5G
- Price
- $600
- Updated
- 2021/12/16
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE Chemical Properties,Usage,Production
Synthesis
506-68-3
1575-37-7
791595-74-9
Step A: Synthesis of 5-bromo-1H-benzimidazol-2-amine [00400] 4-Bromo-1,2-benzenediamine (4 g, 21.39 mmol) was dissolved in methanol (20 mL) to form a dark brown solution. Cyanogen bromide (2.492 g, 23.52 mmol) was added to this solution. The reaction was exothermic and the methanol began to boil after a few seconds. After 5 minutes of reaction, the reaction mixture was diluted with ethyl acetate (100 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution (100 mL) and saturated sodium chloride solution (100 mL). After concentrating the organic layer to a few mL, it was purified by silica gel column chromatography (0-20% methanol/ethyl acetate gradient elution) to afford 5-bromo-1H-benzimidazol-2-amine (3.9 g, 18.39 mmol, 86% yield) as a black solid. 1H NMR (400 MHz, DMSO-d6) δ ppm: 6.47 (br.s., 2H), 6.94-7.00 (m, 1H), 7.01-7.06 (m, 1H), 7.23 (d, J = 1.85 Hz, 1H), 8.70-11.33 (m, 1H); ES LC-MS m/z = 212.2 (Br 79, M + H)+, ES LC-MS m/z = 214.2 (Br 81, M + H)+.
References
[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 21, p. 5226 - 5229
[2] Patent: US2013/136782, 2013, A1. Location in patent: Paragraph 0216; 0217
[3] Patent: WO2012/174312, 2012, A2. Location in patent: Page/Page column 283-284
[4] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 219-220
[5] Advanced Synthesis and Catalysis, 2018, vol. 360, # 10, p. 1943 - 1948
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE manufacturers
- Product
- 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE 791595-74-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09