5,6-DEHYDROARACHIDONIC ACID

Product Name: 5,6-DEHYDROARACHIDONIC ACID
CAS No.: 58688-54-3
Chemical Name: 5,6-DEHYDROARACHIDONIC ACID
Synonyms: 5,6-dehydro aa;5,6-DEHYDROARACHIDONIC ACID;GIOQWSLKUVKKAO-QNEBEIHSSA-N;eicosa-8,11,14-trien-5-ynoic acid;8Z,11Z,14Z-EICOSATRIEN-5-YNOIC ACID;CIS-8,11,14-EICOSATRIEN-5-YNOIC ACID;8,11,14-Eicosatrien-5-ynoic acid, (8Z,11Z,14Z)-;5,6-dehydro AA, cis-8,11,14-Eicosatrien-5-ynoic acid;5,6 dehydro Arachidonic Acid,5,6dehydro Arachidonic Acid
CBNumber: CB7674299
Molecular Formula: C20H30O2
Formula Weight: 302.45
MOL File: 58688-54-3.mol

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5,6-DEHYDROARACHIDONIC ACID Property

Flash point:: 17 °C
storage temp.: −20°C
solubility: 0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid); DMF: >100 mg/ml (from Oleic Acid); DMSO: >100 mg/ml (from Oleic Acid); Ethanol: >100 mg/ml (from Oleic Acid); PBS pH 7.2: <100 μg/ml (from Oleic Acid)
form: ethanol solution

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Safety

Hazard Codes: F
Risk Statements: 11-16
Safety Statements: 16-7
RIDADR: UN 1170 3/PG 2
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D2154
Product name: 5,6-Dehydroarachidonic acid
Purity: ≥98%, ethanol solution
Packaging: 100μg
Price: $644
Updated: 2024/03/01

Sigma-Aldrich

Product number: D2154
Product name: 5,6-Dehydroarachidonic acid
Purity: ≥98%, ethanol solution
Packaging: 25μg
Price: $249
Updated: 2023/01/07

Cayman Chemical

Product number: 90020
Product name: 5,6-dehydro Arachidonic Acid
Purity: ≥98%
Packaging: 25μg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 90020
Product name: 5,6-dehydro Arachidonic Acid
Purity: ≥98%
Packaging: 50μg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 90020
Product name: 5,6-dehydro Arachidonic Acid
Purity: ≥98%
Packaging: 100μg
Price: $351
Updated: 2024/03/01

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5,6-DEHYDROARACHIDONIC ACID Chemical Properties,Usage,Production

Uses

5,6-Dehydroarachidonic acid is a 5-lipoxygenase (Lipoxygenase) inhibitor that inhibits the biosynthesis of leukotrienes. However, 5,6-Dehydroarachidonic acid had no effect on vascular cell proliferation[1][2][3].

Definition

ChEBI: 5,6-dehydro Arachidonic Acid is a long-chain fatty acid.

Biological Activity

Inhibits 5-lipoxygenase of guinea pig leukocytes with an IC50 of 10 μM. In extracts of r at basophilic leukemia cells preincubated with 5,6-dehydro AA, the Ki for the conversion of arachidonic acid to 5-HPETE is 15 μM.

References

[1] Sok DE, et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem Biophys Res Commun. 1982 Jul 16;107(1):101-8. DOI:10.1016/0006-291x(82)91675-8
[2] Dethlefsen SM, et al. Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth. Exp Cell Res. 1994 Jun;212(2):262-73. DOI:10.1006/excr.1994.1142
[3] Corey E J, et al. Synthesis of three potential inhibitors of the biosynthesis of leukotrienes A–E[J]. Tetrahedron Letters, 1980, 21(44): 4243-4246.

5,6-DEHYDROARACHIDONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6-DEHYDROARACHIDONIC ACID Suppliers

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58688-54-3, 5,6-DEHYDROARACHIDONIC ACIDRelated Search:

5-HEXYN-1-OL 1-HEXEN-4-YNE 1-PENTEN-4-YNE 1-OCTEN-4-YNE 5-HEXYNOIC ACID 1-NONEN-4-YNE 1-HEPTEN-4-YNE 5,6-DEHYDROARACHIDONIC ACID

5,6-dehydro aa

eicosa-8,11,14-trien-5-ynoic acid

5,6-dehydro AA, cis-8,11,14-Eicosatrien-5-ynoic acid

CIS-8,11,14-EICOSATRIEN-5-YNOIC ACID

GIOQWSLKUVKKAO-QNEBEIHSSA-N

8Z,11Z,14Z-EICOSATRIEN-5-YNOIC ACID

5,6-DEHYDROARACHIDONIC ACID

8,11,14-Eicosatrien-5-ynoic acid, (8Z,11Z,14Z)-

5,6 dehydro Arachidonic Acid,5,6dehydro Arachidonic Acid

58688-54-3

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

BioChemical

Biochemicals and Reagents

Lipoxygenase (5-)

L to O