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ChemicalBook > CAS DataBase List > 5-Chloro-1H-indazole-3-carboxylic acid

5-Chloro-1H-indazole-3-carboxylic acid

Application
Product Name
5-Chloro-1H-indazole-3-carboxylic acid
CAS No.
1077-95-8
Chemical Name
5-Chloro-1H-indazole-3-carboxylic acid
Synonyms
5-CHLORO-3-INDAZOLECARBOXYLIC ACID;5-CHLORO-3-INDOZOLE-CARBOXYLIC ACID;5-chloro-1H-indazol-3-carboxylic acid;5-chloro-1h-indazole-3-carboxylic acod;5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID;1H-Indazole-3-carboxylic acid, 5-chloro-;5-Chloro-1H-indazole-3-carboxylic acid ,97%
CBNumber
CB7675256
Molecular Formula
C8H5ClN2O2
Formula Weight
196.59
MOL File
1077-95-8.mol
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5-Chloro-1H-indazole-3-carboxylic acid Property

Melting point:
337 °C
Boiling point:
472.1±25.0 °C(Predicted)
Density 
1.644±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
2.82±0.30(Predicted)
color 
Yellow
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Safety

Risk Statements 
22-36
Safety Statements 
26
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C421903
Product name
5-Chloro-1h-indazole-3-carboxylicacid
Packaging
100mg
Price
$95
Updated
2021/12/16
Apolloscientific
Product number
OR912768
Product name
5-Chloro-1H-indazole-3-carboxylicacid
Purity
95%
Packaging
250mg
Price
$32
Updated
2021/12/16
Apolloscientific
Product number
OR912768
Product name
5-Chloro-1H-indazole-3-carboxylicacid
Purity
95%
Packaging
1g
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC35231
Product name
5-chloro-1h-indazole-3-carboxylic acod
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
Y6984
Product name
5-Chloro-1H-indazole-3-carboxylicacid
Packaging
1g
Price
$171
Updated
2021/12/16
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5-Chloro-1H-indazole-3-carboxylic acid Chemical Properties,Usage,Production

Application

5-Chloro-1H-indazole-3-carboxylic acid is an important pharmaceutical intermediate used to construct the core of active drug molecules.

Chemical Properties

Light yellow solid

Synthesis

1H-indazole-3-carboxylic acid was dissolved in anhydrous acetic acid in a three-necked flask, heated and stirred. After the substrate was dissolved and clarified, phosphorus oxychloride was dissolved in anhydrous acetic acid and slowly added dropwise. In an oil bath at 90°C, the mixture was condensed back into the chemical book and reacted for 14 hours. After the reaction was complete, a white precipitate was produced. It was cooled in an ice bath, vacuum filtered, and the solid was washed with ethyl acetate first and then with ether to obtain 5-Chloro-1H-indazole-3-carboxylic acid.

References

[1] Patent: WO2005/14554, 2005, A1. Location in patent: Page/Page column 60-61
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0356
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6259 - 6272
[4] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 97

5-Chloro-1H-indazole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate 5-Chloroisatin Sodium nitrite Hydrochloric acid Sulfuric acid

Preparation Products

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5-Chloro-1H-indazole-3-carboxylic acid Suppliers

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View Lastest Price from 5-Chloro-1H-indazole-3-carboxylic acid manufacturers

Career Henan Chemical Co
Product
5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID 1077-95-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2019-08-05

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