SHU-9119

ChemicalBook > CAS DataBase List > SHU-9119

Product Name: SHU-9119
CAS No.: 168482-23-3
Chemical Name: SHU-9119
Synonyms: SHU-9119;SHU9119，TFA;CHEMBL3422426;SHU9119 (trifluoroacetate salt);AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2;AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG;AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2;Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2);AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2;AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
CBNumber: CB7675726
Molecular Formula: C54H71N15O9
Formula Weight: 1074.24
MOL File: 168482-23-3.mol

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SHU-9119 Property

Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
form: Powder
pka: 13.00±0.70(Predicted)
color: White to off-white
Water Solubility: Soluble to 0.20 mg/ml in water
Sequence: Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24152
Product name: SHU9119 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 500μg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 24152
Product name: SHU9119 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Tocris

Product number: 3420
Product name: SHU9119
Packaging: 1
Price: $151
Updated: 2021/12/16

Usbiological

Product number: 256659
Product name: SHU 9119
Packaging: 1mg
Price: $389
Updated: 2021/12/16

ChemScene

Product number: CS-6496
Product name: SHU9119
Purity: 98.21%
Packaging: 5mg
Price: $468
Updated: 2021/12/16

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SHU-9119 Chemical Properties,Usage,Production

Description

SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC₅₀s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC₅₀ = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.

storage

Store at -20°C

SHU-9119 Preparation Products And Raw materials

Raw materials

Preparation Products

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SHU-9119 Suppliers

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168482-23-3, SHU-9119Related Search:

ALPHA-MSH ALPHA-MSH SHU 9119, [125I]- SHU-9119 Melanotan II

SHU-9119

[N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM

AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2

AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM

AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG

AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2

(AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE

AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10)

(AC-NLE4,ASP5,D-ALA(2-NAPHTHYL)7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE

AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2

AC-NLE-CYCLO(-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2) TRIFLUOROACETATE SALT

AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2

AC-NLE-CYCLO(BETA-ASP-HIS-D-2-NAL-ARG-TRP-EPSILON-LYS)-NH2

AC-NLE-CYCLO(-BETA-ASP-HIS-D-ALA(2-NAPHTHYL)-ARG-TRP-EPSILON-LYS-NH2)

[ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE

[ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MSH (4-10) AMIDE

(ACETYL-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE TRIFLUOROACETATE SALT

(Ac-Nle4,Asp5,D-Ala(2-naphthyl)7,Lys10)-cyclo-a-MSH (4-10) amide

Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) aMide SHU9119

Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-a-MSH (4-10) aMide

Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2)

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-Alpha-MSH (4-10) amide

SHU9119 (trifluoroacetate salt)

L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide trifluoroacetate salt

CHEMBL3422426

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide

Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide, SHU9119

Acetyl-(Nle?,Asp?,D-2-Nal?,Lys1?)-cyclo-α-MSH (4-10) amide trifluoroacetate salt

Acetyl-(Nle?,Asp?,D-2-Nal?,Lys??)-cyclo-α-MSH (4-10) amide trifluoroacetate salt

SHU9119，TFA

(3R,6R,9S,12R,15R,23R)-12-((1H-Imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((R)-2-acetamidohexanamido)-6-(3-guanidinopropyl)-9-(naphthalen-2-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxamide

168482-23-3

C54H71N15O9