ChemicalBook > CAS DataBase List > SHU-9119

SHU-9119

Product Name
SHU-9119
CAS No.
168482-23-3
Chemical Name
SHU-9119
Synonyms
SHU-9119;SHU9119,TFA;CHEMBL3422426;SHU9119 (trifluoroacetate salt);AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2;AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG;AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2;Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2);AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2;AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
CBNumber
CB7675726
Molecular Formula
C54H71N15O9
Formula Weight
1074.24
MOL File
168482-23-3.mol
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SHU-9119 Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O : 20 mg/mL (18.62 mM; Need ultrasonic)
form 
Powder
pka
13.00±0.70(Predicted)
Water Solubility 
Soluble to 0.20 mg/ml in water
Sequence
Ac-Nle-Asp-His-D-Nal-Arg-Trp-Lys-NH2(Chemical Bridge Asp2-Lys7)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24152
Product name
SHU9119 (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$77
Updated
2024/03/01
Cayman Chemical
Product number
24152
Product name
SHU9119 (trifluoroacetate salt)
Purity
≥95%
Packaging
1mg
Price
$121
Updated
2024/03/01
Tocris
Product number
3420
Product name
SHU9119
Packaging
1
Price
$151
Updated
2021/12/16
Usbiological
Product number
256659
Product name
SHU 9119
Packaging
1mg
Price
$389
Updated
2021/12/16
ChemScene
Product number
CS-6496
Product name
SHU9119
Purity
98.21%
Packaging
5mg
Price
$468
Updated
2021/12/16
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SHU-9119 Chemical Properties,Usage,Production

Description

SHU9119 is an agonist of melanocortin receptor 1 (MC1R) and antagonist of MC4R (IC50s = 1.2 and 2.9 nM, respectively, for displacement of melanocortin). It induces cAMP formation in HEK293 cells expressing human MC1R (EC50 = 1.11 nM), but inhibits cAMP formation in cells expressing human MC4R. In rats, SHU9119 (24 nmol, i.c.v. per day for seven days) increases food intake, body weight, fat mass, and lean mass, with concomitant increases in blood glucose, insulin, and leptin levels via disrupted melanocortin signaling. Similarly, mice treated with SHU9119 (5 nmol/day, i.c.v.) exhibit food intake-independent increases in body weight and fat mass consequent to MC4R inhibition and subsequent brown adipose tissue dysfunction.

storage

Store at -20°C

SHU-9119 Preparation Products And Raw materials

Raw materials

Preparation Products

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SHU-9119 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
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Career Henan Chemica Co
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168482-23-3, SHU-9119Related Search:


  • SHU-9119
  • [N-ACETYL-NLE4,ASP5,D-2'-NAL7,LYS10]-ALPHA-MSH (4-10) AMIDE, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2
  • AC-NLE-ASP-HIS-D-2'-NAL-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
  • AC-NLE-ASP-HIS-D-2-NAL-H2N-LYS-TRP-ARG
  • AC-NLE-ASP-HIS-D-NAL(2)-ARG-TRP-LYS-NH2
  • (AC-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
  • AC-[NLE4, ASP5, D-2-NAL7, LYS10]-CYCLO-ALPHA-MSH AMIDE (4-10)
  • (AC-NLE4,ASP5,D-ALA(2-NAPHTHYL)7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
  • AC-NLE4-C[ASP5, D-NAL(2)7, LYS10]ALPHA-MSH (4-10)-NH2
  • AC-NLE-CYCLO(-ASP-HIS-D-2-NAL-ARG-TRP-LYS-NH2) TRIFLUOROACETATE SALT
  • AC-NLE-CYCLO[(BETA-D)-H-(D-2-NAL)-RW-(EPSILON-K)]-NH2
  • AC-NLE-CYCLO(BETA-ASP-HIS-D-2-NAL-ARG-TRP-EPSILON-LYS)-NH2
  • AC-NLE-CYCLO(-BETA-ASP-HIS-D-ALA(2-NAPHTHYL)-ARG-TRP-EPSILON-LYS-NH2)
  • [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MELANOCYTE STIMULATING HORMONE (4-10) AMIDE
  • [ACETYL-NLE4, ASP5, D-2-NAL7, LYS10]-ALPHA-MSH (4-10) AMIDE
  • (ACETYL-NLE4,ASP5,D-2-NAL7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE TRIFLUOROACETATE SALT
  • (Ac-Nle4,Asp5,D-Ala(2-naphthyl)7,Lys10)-cyclo-a-MSH (4-10) amide
  • Acetyl-[Nle4, Asp5, D-2-Nal7, Lys10]-cyclo-α-Melanocyte Stimulating Hormone Amide Fragment 4-10
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) aMide SHU9119
  • Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2 (AMide bond Asp5-Lys10)
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-a-MSH (4-10) aMide
  • Ac-Nle-cyclo(-Asp-His-D-2-Nal-Arg-Trp-Lys-NH2)
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-Alpha-MSH (4-10) amide
  • SHU9119 (trifluoroacetate salt)
  • L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
  • CHEMBL3422426
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide
  • Acetyl-(Nle4,Asp5,D-2-Nal7,Lys10)-cyclo-α-MSH (4-10) amide, SHU9119
  • Acetyl-(Nle?,Asp?,D-2-Nal?,Lys1?)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
  • Acetyl-(Nle?,Asp?,D-2-Nal?,Lys??)-cyclo-α-MSH (4-10) amide trifluoroacetate salt
  • SHU9119,TFA
  • 168482-23-3
  • C54H71N15O9