5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE

Product Name: 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE
CAS No.: 21734-85-0
Chemical Name: 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE
Synonyms: 5-chloro-3-methyl-1,2,4-thiazole;5-Chlor-3-methyl-[1,2,4]thiadiazol;5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE;2-chloro-5-methyl-1,2,4- thiodiazole;1,2,4-Thiadiazole, 5-chloro-3-methyl-
CBNumber: CB7676596
Molecular Formula: C3H3ClN2S
Formula Weight: 134.59
MOL File: 21734-85-0.mol

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5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE Property

Boiling point:: 51 °C(Press: 21 Torr)
Density: 1.355 g/cm3
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.36±0.10(Predicted)
form: liquid
color: Pale yellow

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000670
Product name: 5-Chloro-3-methyl-1,2,4-thiadiazole
Packaging: 1 g
Price: $330
Updated: 2025/07/31

TRC

Product number: C373518
Product name: 5-chloro-3-methyl-1,2,4-thiadiazole
Packaging: 25mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H70-5-Y9
Product name: 5-Chloro-3-methyl-1,2,4-thiadiazole
Packaging: 1g
Price: $368
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC153723
Product name: 5-Chloro-3-methyl-1,2,4-thiadiazole
Packaging: 2g
Price: $405
Updated: 2021/12/16

Matrix Scientific

Product number: 072429
Product name: 5-Chloro-3-methyl-1,2,4-thiadiazole
Purity: 95+%
Packaging: 1g
Price: $416
Updated: 2021/12/16

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5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE Chemical Properties,Usage,Production

Synthesis

124-42-5

594-42-3

21734-85-0

The general procedure for the synthesis of 5-chloro-3-methyl-1,2,4-thiadiazole from acetamidine hydrochloride and perchloromethylmercaptan was as follows: to a stirred mixture of acetamidine hydrochloride (38.1 g, 0.40 mol) and trichloromethanesulfonyl chloride (75 g, 0.40 mol) at ±5°C, an aqueous solution containing NaOH (75.7 g, 0.40 mol) was slowly added dropwise (126mL). After the dropwise addition, the reaction mixture was stirred at 0°C for 30 minutes and then allowed to warm up to room temperature. After completion of the reaction, the mixture was filtered and the layers were separated. The aqueous phase was extracted with dichloromethane (3 x 150 mL). All organic phases were combined and washed with brine (2 x 150 mL) and subsequently dried with anhydrous magnesium sulfate. Finally, the solvent was removed under reduced pressure to afford the target product 5-chloro-3-methyl-1,2,4-thiadiazole (43 g, 83% yield) as a dark colored oil.

References

[1] Patent: US2010/160392, 2010, A1. Location in patent: Page/Page column 18
[2] Patent: WO2007/100670, 2007, A1. Location in patent: Page/Page column 48
[3] Patent: WO2005/7636, 2005, A1. Location in patent: Page/Page column 14; 15
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 9, p. 1887 - 1900
[5] Chemische Berichte, 1957, vol. 90, p. 182,186

5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE Suppliers

China 65 Europe 2 Germany 2 India 1 United Kingdom 3 United States 10 Global 83

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
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Shanghai Ennopharm Co., Ltd.

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China Langchem Inc.

Tel: 0086-21-58956006
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Country: China
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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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NovoChemy Ltd.

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Bide Pharmatech Ltd.

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Shanghai YuYuan Pharmaceutical Co., Ltd.

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ShangHai AmK Pharmaceutical Technology Co., Ltd.

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View Lastest Price from 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE manufacturers

Honest Joy Holdings Limited

Product: 5-Chloro-3-methyl-1,2,4-thiadiazole 21734-85-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.5%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE 21734-85-0
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

21734-85-0, 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLERelated Search:

5-Chloro-2-methyl-4-isothiazolin-3-one 5-CHLORO-3-TRIFLUOROMETHYL-[1,2,4]-THIADIAZOLE 5-CHLORO-3-(CHLOROMETHYL)-1,2,4-THIADIAZOLE 5-Chloro-3-ethyl-1,2,4-thiadiazole 3-(1-ADAMANTYL)-5-CHLORO-1,2,4-THIADIAZOLE 5-CHLORO-3-(2-THIENYL)-1,2,4-THIADIAZOLE 5-(5-CHLORO-1,2,4-THIADIAZOL-3-YL)THIOPHENE-2-SULFONYL CHLORIDE 5-CHLORO-3-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOLE 5-CHLORO-N-METHYL-1,2,3-THIADIAZOLE-4-CARBOXAMIDE 5-CHLORO-4-METHYL-1,2,3-THIADIAZOLE 5-[CHLORO(DIFLUORO)METHYL]-1,3,4-THIADIAZOLE-2-THIOL 5-Chloro-3-isopropyl-1,2,4-thiadiazole 5-CHLORO-3-(TRICHLOROMETHYL)-1,2,4-THIADIAZOLE 5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE

5-Chlor-3-methyl-[1,2,4]thiadiazol

1,2,4-Thiadiazole, 5-chloro-3-methyl-

5-CHLORO-3-METHYL-1,2,4-THIADIAZOLE

5-chloro-3-methyl-1,2,4-thiazole

2-chloro-5-methyl-1,2,4- thiodiazole

21734-85-0