3-CHLORO-5-NITRO-1H-INDAZOLE
- Product Name
- 3-CHLORO-5-NITRO-1H-INDAZOLE
- CAS No.
- 4812-45-7
- Chemical Name
- 3-CHLORO-5-NITRO-1H-INDAZOLE
- Synonyms
- 3-chloro-5-nitroindazole;3-chloro-5-nitro-indazol;3-CHLORO-5-NITRO-1H-INDAZOLE;1H-INDAZOLE,3-CHLORO-5-NITRO;3-Chloro-5-nitro-1H-indazole ,97%
- CBNumber
- CB7677164
- Molecular Formula
- C7H4ClN3O2
- Formula Weight
- 197.58
- MOL File
- 4812-45-7.mol
3-CHLORO-5-NITRO-1H-INDAZOLE Property
- Melting point:
- 218-220
- Boiling point:
- 415.2±25.0 °C(Predicted)
- Density
- 1.661±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9?+-.0.40(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C373958
- Product name
- 3-Chloro-5-nitro-1H-indazole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 046885
- Product name
- 3-Chloro-5-nitro-1H-indazole
- Purity
- >95%
- Packaging
- 500mg
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 046885
- Product name
- 3-Chloro-5-nitro-1H-indazole
- Purity
- >95%
- Packaging
- 1g
- Price
- $33
- Updated
- 2021/12/16
- Product number
- OR14094
- Product name
- 3-Chloro-5-nitro-1H-indazole
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 4H55-5-Y4
- Product name
- 3-Chloro-5-nitro-1H-indazole
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
3-CHLORO-5-NITRO-1H-INDAZOLE Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Synthesis
5401-94-5
4812-45-7
Example 112A Synthesis of 3-chloro-5-nitro-1H-indazole: Sodium hydroxide (5.00 g, 125 mmol) was dissolved in water (150 mL), 5-nitroindazole (5.00 g, 30.7 mmol) was added, and the mixture was heated until a red solution formed. The reaction mixture was cooled in an ice water bath for 15 minutes, followed by the slow addition of sodium hypochlorite solution (60.0 mL, 5.25%, 45.0 mmol). The reaction mixture was stirred at 0 °C for 5 h. After completion of the reaction, the pH was adjusted with dilute hydrochloric acid to 7. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed with water and concentrated under reduced pressure. The residue was purified by fast column chromatography to afford the target compound 3-chloro-5-nitro-1H-indazole (5.5 g, 92% yield). The product was identified by 1H NMR (300 MHz, DMSO-d6): δ 7.78 (m, 1H), 8.28 (m, 1H), 8.61 (m, 1H); mass spectrum (DCI/NH3) showed m/z 197 [M + H]+.
References
[1] Patent: US2005/137243, 2005, A1. Location in patent: Page/Page column 47
[2] Patent: US2005/277638, 2005, A1. Location in patent: Page/Page column 48
[3] European Journal of Medicinal Chemistry, 1983, vol. 18, # 5, p. 469 - 470
[4] Journal of Chemical Research, Miniprint, 1990, # 11, p. 2601 - 2615
[5] European Journal of Medicinal Chemistry, 1986, vol. 21, # 4, p. 359 - 362
3-CHLORO-5-NITRO-1H-INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CHLORO-5-NITRO-1H-INDAZOLE manufacturers
- Product
- 3-chloro-5-nitro-1H-indazole 4812-45-7
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-26
- Product
- 3-Chloro-5-nitro-1H-indazole 4812-45-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%min
- Supply Ability
- 1-10000kgs
- Release date
- 2023-04-03
- Product
- 3-CHLORO-5-NITRO-1H-INDAZOLE 4812-45-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21