ChemicalBook > CAS DataBase List > ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
- Product Name
- ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
- CAS No.
- 310427-94-2
- Chemical Name
- ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
- Synonyms
- β-Secretase Substrate IV, Fluorogenic;Arg-Glu(Edans)-(Asn670, Leu671)-Amyloidb/A4 Protei;ARG-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-ARG;ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG;H-ARG-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-ARG-OH;Arg-Glu: EDANS-: Asn670,Leu671-Amyloid b/A4 Protein Precursor770: 668-675-Lys: DABCYL-Arg;Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg;ARG-GLU(EDANS)-(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (668-675)-LYS (DABCYL)-ARG;Arg-Glu(EDANS)-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 669-674-(DABCYL)Lys-Arg;ARG-GLU(EDANS)-[ASN670, LEU671]-AMYLOID B/A4 PROTEIN PRECURSOR 770 FRAGMENT 669-674-(DABCYL)LYS-ARG
- CBNumber
- CB7679456
- Molecular Formula
- C91H129N25O25S
- Formula Weight
- 2005.22
- MOL File
- 310427-94-2.mol
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ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Property
- storage temp.
- −20°C
- solubility
- DMSO: 5mg/mL
- form
- solid
- color
- red
- Sequence
- Arg-{Glu(EDANS)}-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-{Lys(DABCYL)}-Arg
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Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 565758
- Product name
- β-Secretase Substrate IV, Fluorogenic
- Purity
- A highly sensitive fluorescence resonance energy transfer (FRET) peptide substrate, based on the EVNLDAEF sequence derived from the β-secretase site of the Swedish mutation of Amyloid Precursor
- Packaging
- 1 mg
- Price
- $246
- Updated
- 2025/07/31
Biosynth Carbosynth
- Product number
- FA110960
- Product name
- Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
- Packaging
- 250ug
- Price
- $175
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA110960
- Product name
- Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
- Packaging
- 500ug
- Price
- $300
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA110960
- Product name
- Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
- Packaging
- 1mg
- Price
- $525
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- PEP0000087
- Product name
- [ARG666, GLU667, ASN670, LEU671,LYS676, ARG677] - BETA- AMYLOID PRECURSOR PROTEIN(666-677), FRET, DABCYL/ EDANS LABELED
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $693
- Updated
- 2021/12/16
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ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Chemical Properties,Usage,Production
Uses
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction[1].
Biological Activity
Cell permeable: no', 'Primary Target
β-secretase substrate', 'Product does not compete with ATP.', 'Reversible: no
References
[1] Ortega A, et.al. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2183-7. DOI:10.1016/j.bmcl.2011.03.023
ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Preparation Products And Raw materials
Raw materials
Preparation Products
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ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Suppliers
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- Country
- Switzerland
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