ChemicalBook > CAS DataBase List > 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE

3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE

Product Name: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE
CAS No.: 204862-70-4
Chemical Name: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE
Synonyms: 3,5-Dimethoxyisonicotinaldehyde;3,5-dimethoxypyridine-4-carbaldehyde;3,5-Dimethoxy-4-pyridinecarboxaldehyde;3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE;4-Pyridinecarboxaldehyde, 3,5-dimethoxy-;2-forMyl-3,5-diMethoxypyridine-4-carboxylic acid
CBNumber: CB7680234
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 204862-70-4.mol

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3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE Property

Boiling point:: 319.6±37.0 °C(Predicted)
Density: 1.174
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.09±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD151404
Product name: 3,5-Dimethoxypyridine-4-carboxaldehyde
Packaging: 10mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151404
Product name: 3,5-Dimethoxypyridine-4-carboxaldehyde
Packaging: 25mg
Price: $149
Updated: 2021/12/16

AK Scientific

Product number: 9449AJ
Product name: 3,5-Dimethoxyisonicotinaldehyde
Packaging: 100mg
Price: $258
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD151404
Product name: 3,5-Dimethoxypyridine-4-carboxaldehyde
Packaging: 50mg
Price: $259
Updated: 2021/12/16

AK Scientific

Product number: 9449AJ
Product name: 3,5-Dimethoxyisonicotinaldehyde
Packaging: 250mg
Price: $382
Updated: 2021/12/16

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3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE Chemical Properties,Usage,Production

Synthesis

18677-48-0

68-12-2

204862-70-4

To a solution of 3,5-dimethoxypyridine (3.6 g, 25.90 mmol, 1 eq.) in tetrahydrofuran (THF, 80 mL) was slowly added n-butyllithium (BuLi, 3M hexane solution, 13.0 mL, 38.85 mmol, 1.5 eq.) at -20 °C. The reaction mixture was slowly warmed to 0 °C and stirred at this temperature for 30 minutes. Subsequently, the reaction system was cooled to -78 °C and N,N-dimethylformamide (DMF, 3.8 g, 51.8 mmol, 2 eq.) was added dropwise. The reaction mixture was gradually warmed to 0 °C and the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) and diluted with ethyl acetate (EtOAc). The aqueous phase was extracted twice with ethyl acetate (EtOAc). The organic phases were combined, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a solvent mixture of ethyl acetate (EtOAc) and hexane as eluent to afford 3,5-dimethoxypyridine-4-carbaldehyde (2.7 g, 62% yield) as a yellow solid. Low resolution mass spectrometry (LRMS) showed (M+H)+ m/z 168.1.

References

[1] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0316
[2] Patent: US2015/344483, 2015, A1. Location in patent: Paragraph 0584; 0585
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 321 - 326
[4] Patent: WO2007/30582, 2007, A2. Location in patent: Page/Page column 89

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Raw materials

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View Lastest Price from 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE manufacturers

Career Henan Chemical Co

Product: 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE 204862-70-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-02

204862-70-4, 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDERelated Search:

2,6-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE 2 6-DIMETHOXYPYRIDINE-3-CARBOXALDEHYDE& 3,5-DIHYDROXYPYRIDINE 3,5-Dimethoxypyridine 3-METHOXYISONICOTINALDEHYDE 3,5-Diethoxypyridine-4-carboxaldehyde 3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE 5-METHOXY-PYRIDIN-3-OL

3,5-DIMETHOXYPYRIDINE-4-CARBOXALDEHYDE

3,5-Dimethoxy-4-pyridinecarboxaldehyde

3,5-Dimethoxyisonicotinaldehyde

2-forMyl-3,5-diMethoxypyridine-4-carboxylic acid

4-Pyridinecarboxaldehyde, 3,5-dimethoxy-

3,5-dimethoxypyridine-4-carbaldehyde

204862-70-4

Pyridines