3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE
- Product Name
- 3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE
- CAS No.
- 4568-71-2
- Chemical Name
- 3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE
- Synonyms
- 3-Benzyl-5-(hydroxyethyl)-4-methylthiazolium chloride;3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride;3-Benzyl-4-methyl-5-(2-hydroxyethyl)thiazole-3-ium·chloride;Nsc172802;-3-ium chL;-5-(2-hydroxyethyL;LABOTEST-BB LT00452912;3-Benzyl-5(2-OHEt)-4-mEtthiazolium Cl;3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIA;2-(3-benzyl-4-methyl-thiazol-3-ium-5-yl)ethanol
- CBNumber
- CB7689262
- Molecular Formula
- C13H16ClNOS
- Formula Weight
- 269.79
- MOL File
- 4568-71-2.mol
3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE Property
- Melting point:
- 142-144 °C(lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- sol H2O, MeOH, EtOH; slightly sol cold MeCN; insol ether, pentane
- form
- Crystalline Powder
- color
- White
- Water Solubility
- Soluble in water.
- Sensitive
- Hygroscopic
- BRN
- 3788921
- InChI
- InChI=1S/C13H16NOS.ClH/c1-11-13(7-8-15)16-10-14(11)9-12-5-3-2-4-6-12;/h2-6,10,15H,7-9H2,1H3;1H/q+1;/p-1
- InChIKey
- IWSVLBKHBJGMAA-UHFFFAOYSA-M
- SMILES
- [N+]1(=CSC(CCO)=C1C)CC1=CC=CC=C1.[Cl-]
- CAS DataBase Reference
- 4568-71-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 256234
- Product name
- 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $109.25
- Updated
- 2025/07/31
- Product number
- B1224
- Product name
- 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium Chloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- 8H33-5-04
- Product name
- 3-Benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
- Packaging
- 25g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 8H33-5-04
- Product name
- 3-Benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- AK167097
- Product name
- 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazol-3-iumchloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $17
- Updated
- 2021/12/16
3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE Chemical Properties,Usage,Production
Uses
3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride, aliphatic aldehydes undergo the acyloin condensation in the presence of this catalyst and mild base. It acts as a catalyst for the addition of aliphatic and heterocyclic aldehydes to α,β-unsaturated ketones, nitriles and esters.
Synthesis
333385-00-5
100-44-7
4568-71-2
Methyl hydroxyethyl thiazole (2.86 kg), acetonitrile (8.58 kg) and benzyl chloride (2.54 kg) were mixed in a 20 L reactor fitted with a stirrer and heated to reflux for 6.5 hours. After completion of the reaction, the reaction solution was cooled to room temperature and a solid was precipitated. Acetonitrile (3 kg) was added to the reaction solution, stirred and filtered. The resulting solid was washed with acetonitrile (2.0 kg) and then dried under reduced pressure to finally obtain 3-benzyl-5-(2-hydroxyethyl)-4-methylthiazole chloride (2.36 kg, 44% yield).
Purification Methods
Purify the chloride by recrystallisation from EtOH or H2O. If placed in a bath at 125o and heated at 2o/minute, the melting point is 140.5-141.4o. [Livermore & Sealock J Biol Chem 167 699 1947, Maier & Metzler J Am Chem Soc 79 4386 1957, Beilstein 27 III/IV 1758.]
References
[1] Patent: JP5814080, 2015, B2. Location in patent: Paragraph 0062
3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE manufacturers
- Product
- 3-BENZYL-5-(2-HYDROXYETHYL)-4-METHYLTHIAZOLIUM CHLORIDE 4568-71-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-13