5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

Product Name: 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.: 101083-92-5
Chemical Name: 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms: 5-NITRO-7-AZAINDOLE;5-Nitro-7-azaindole,97%;5-Nitro-7-aza-1H-indole;5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 5-nitro-;5-nitro-1H-pyrrolo[2,3-b]pyridine 97%min;TIANFU-CHEM 101083-92-5 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
CBNumber: CB7690297
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 101083-92-5.mol

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5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Property

Melting point:: 280℃
Boiling point:: 392.8±35.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 0.65±0.20(Predicted)
color: yellow
InChI: InChI=1S/C7H5N3O2/c11-10(12)6-3-5-1-2-8-7(5)9-4-6/h1-4H,(H,8,9)
InChIKey: INMIPMLIYKQQID-UHFFFAOYSA-N
SMILES: C12NC=CC1=CC([N+]([O-])=O)=CN=2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: N520120
Product name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine
Packaging: 100mg
Price: $165
Updated: 2021/12/16

ChemScene

Product number: CS-B0505
Product name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine
Purity: 96.39%
Packaging: 1g
Price: $27
Updated: 2021/12/16

Apolloscientific

Product number: OR308037
Product name: 5-Nitro-1H-pyrrolo[2,3-b]pyridine
Packaging: 1g
Price: $73
Updated: 2021/12/16

Matrix Scientific

Product number: 068654
Product name: 5-Nitro-7-azaindole
Purity: >95%
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H55-1-70
Product name: 5-Nitro-7-azaindole
Purity: 97%
Packaging: 1g
Price: $87
Updated: 2021/12/16

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5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production

Uses

5-Nitro-1H-pyrrolo[2,3-b]pyridine is a reagent used in the synthesis of Cdc7 kinase inhibitors used as a novel cancer therapy. Also an intermediate in the synthesis of 4-anilinoquinazolines as potential anticancer agents.

Synthesis

937012-11-8

101083-92-5

To a stirred suspension of 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (10.2 g, 33 mmol) in methanol (250 mL) was added powdered sodium hydroxide (2 g, 50 mmol) in batches. After stirring the reaction mixture for 30 min at room temperature, powdered sodium hydroxide (2 g, 50 mmol) and dichloromethane (50 mL) were added again and stirring was continued for 30 min. Upon completion of the reaction, the mixture was concentrated, followed by the addition of a mixed solution of 2N HCl (50 mL) and water (200 mL), and the resulting mixture was filtered. The yellow filter cake was washed with water and dried to afford 5-nitro-1H-pyrrolo[2,3-b]pyridine (4.6 g, 28.2 mmol, 85% yield). The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 6.78 (dd, J = 3.50, 1.83 Hz, 1H), 7.79 (dd, J = 3.35, 2.59 Hz, 1H), 8.90-8.92 (m, 1H), 9.13 (d, J = 2.59 Hz, 1H), 12.05- 12.92 (m, 1H).

References

[1] Patent: US2007/112020, 2007, A1. Location in patent: Page/Page column 36

5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE Suppliers

China 131 China Hong Kong 1 India 6 United Kingdom 2 United States 14 Global 154

Nanjing SynTitan Pharmaceutical Co., Ltd.

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View Lastest Price from 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers

Career Henan Chemical Co

Product: 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE 101083-92-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

101083-92-5, 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINERelated Search:

5-NITRO-2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE 5-NITRO-2,3-DIHYDRO-1,4-BENZODIOXINE 3-HYDROXY-5-NITROPYRIDINE 5-Nitro-3-(trifluoromethyl)-2-pyridinamine Methyl 5-nitro-2-pyridinecarboxylate 5-NITROBENZOTHIAZOLE 7-Azaindole 6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE 3-nitro-1H-pyrrolo[2,3-b]pyridine 5-chloro-3-nitro-1H-pyrrolo[2,3-b]pyridine 3-AMINO-6-METHYL-5-NITRO-7-AZAINDOLE 3-FORMYL-6-METHYL-5-NITRO-7-AZAINDOLE 6-METHYL-5-NITRO-7-AZAINDOLE 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 6-methyl-5-nitro- 3-BROMO-6-METHYL-5-NITRO-7-AZAINDOLE 3-IODO-6-METHYL-5-NITRO-7-AZAINDOLE 2-Methyl-3-nitro-1H-pyrrolo[2,3-b]pyridine

1H-Pyrrolo[2,3-b]pyridine, 5-nitro-

5-Nitro-7-aza-1H-indole

5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

5-NITRO-7-AZAINDOLE

5-Nitro-7-azaindole,97%

TIANFU-CHEM 101083-92-5 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

5-nitro-1H-pyrrolo[2,3-b]pyridine 97%min

101083-92-5

Azaindoles