L-METHIONINE SULFOXIMINE

Product Name: L-METHIONINE SULFOXIMINE
CAS No.: 15985-39-4
Chemical Name: L-METHIONINE SULFOXIMINE
Synonyms: L-METHIONINE-DL-SULFOXIMINE;L-Methionine [R,S]-Sulfoximine;MSX;L-Methionine Sulfoxime;L-Methionin-sulfoximine;L-METHIONINE SULFOXIMINE;L-Methionine sulfoxiimine;METHIONINE SULFOXIMINE (L);Methionine-rs-sulfoximine, L-;L-Methionine sulfoximine, 98+%
CBNumber: CB7690727
Molecular Formula: C5H12N2O3S
Formula Weight: 180.23
MOL File: 15985-39-4.mol

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L-METHIONINE SULFOXIMINE Property

Melting point:: >210 °C (dec.)(lit.)
Boiling point:: 352.2±52.0 °C(Predicted)
Density: 1.215 (estimate)
refractive index: 1.6430 (estimate)
storage temp.: 20-25°C
solubility: Aqueous Base (Slightly), Formic Acid (Slightly), Water (Sparingly, Sonicated)
form: Crystalline Powder
color: White or almost white
optical activity: [α]20/D +10.8 to +14.0°, c = 1 in H2O
biological source: synthetic
BRN: 6175446
Stability:: Temperature Sensitive
CAS DataBase Reference: 15985-39-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27608
Product name: L-Methionine-(S,R)-Sulfoximine
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27608
Product name: L-Methionine-(S,R)-Sulfoximine
Packaging: 100mg
Price: $57
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5379
Product name: L-Methionine sulfoximine
Packaging: 250mg
Price: $133
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5379
Product name: L-Methionine sulfoximine
Packaging: 500mg
Price: $211
Updated: 2024/03/01

Sigma-Aldrich

Product number: M5379
Product name: L-Methionine sulfoximine
Packaging: 1g
Price: $312
Updated: 2024/03/01

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L-METHIONINE SULFOXIMINE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Powder

Uses

glutamine synthetase inhibitor, ornithine decarboxylase enhancer, convulsant

Uses

L-Methionine sulfoximine has been used as a potent inhibitor of glutamine synthetase (GS) activity.

Uses

Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM). Methionine sulfoximine is also a toxic

Definition

ChEBI: L-methionine sulfoximine is a methionine sulfoximine in which the amino group has S-stereochemistry. It has a role as a geroprotector and an EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor. It is a methionine sulfoximine, a L-methionine derivative and a non-proteinogenic L-alpha-amino acid. It is a tautomer of a L-methionine sulfoximine zwitterion.

Biochem/physiol Actions

As a potent inhibitor of glutamine synthetase activity (GS), this reagent has widely been used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. The growing demand for high yield cell banks for production of recombinant proteins for therapeutics has resulted in two major systems for selection of stable and active clones, Methotrexate selection of dihydrofolate reductase (DHFR) overexpressing cells and MSX selection of glutamine synthetase overexpressing cells. Cells are grown in the absence of glutamine in the media and inhibition of the endogenous activity of glutamine synthetase results in cell death for cells lacking overexpression. The MSX-glutamine synthetase selection mechanism provides benefits over that of the Methotrexate-DHFR system in that it typically requires a single amplification step and results in significant reduction of time to produce high stability, highly amplified clones. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting GS activity. MSX increases ornithine decarboxylase activity and decreases the survival rate in a model of transient cerebral ischemia.

L-METHIONINE SULFOXIMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-METHIONINE SULFOXIMINE Suppliers

Belgium 1 Canada 1 China 134 Germany 1 India 7 Japan 2 Switzerland 1 United Kingdom 3 United States 24 Global 174

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View Lastest Price from L-METHIONINE SULFOXIMINE manufacturers

Career Henan Chemical Co

Product: L-METHIONINE SULFOXIMINE 15985-39-4
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-14

15985-39-4, L-METHIONINE SULFOXIMINERelated Search:

Methanol Dimethyl sulfoxide 4-(METHYLTHIO)BUTANOL DL-METHIONINE SULFOXIDE L-Methioninol L-Methionine DL-Homocysteine 3-aminopropanethiol 3-(METHYLTHIO)PROPYLAMINE Ammonium sulfide N-BUTYL METHYL SULFIDE L-BUTHIONINE-(S,R)-SULFOXIMINE METHYL PROPYL SULFIDE Butanethiol DL-Methionine 4-MERCAPTO-1-BUTANOL 1-Propanethiol L-METHIONINE SULFOXIMINE

2-AMINO-4-(S-METHYLSULFONIMIDOSYL)BUTANOIC ACID

L-S-[3-AMINO-3-CARBOXYPROPYL]-S-METHYLSULFOXIMINE

L-METHIONINE SULFOXIMINE

L-METHIONINE-DL-SULFOXIMINE

L-Methionine [R,S]-Sulfoximine

L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine

(2S)-2-Amino-4-(S-methylsulfonimidosyl)butanoic acid

L-Methionine sulfoximine, 98+%

Butanoic acid, 2-aMino-4-(S-MethylsulfoniMidoyl)-, (2S)-

METHIONINE SULFOXIMINE (L)

Butanoic acid, 2-amino-4-(S-methylsulfonimidoyl)- (9CI)

Methionine-DL-sulfoximine, DL-

Methionine-rs-sulfoximine, L-

Sulfoximine, S-(3-amino-3-carboxypropyl)-S-methyl-, DL-

-2-Amino-4-(S-methylsulfonimidoyl)

L-Methionine Sulfoxime

L-Methionine sulfoxiimine

L-Methionin-sulfoximine

2-amino-4-(methylsulfonimidoyl)butyric acid

(2S)-2-amino-4-[imino(methyl)oxo-λ?-sulfanyl]butanoic acid

L-Methionine-(S,R)-Sulfoximine

L-METHIONINE SULFOXIMINE USP/EP/BP

"L-Methionine [R,S]-Sulfoximine-13C6"

(2S)-2-amino-4-(methylsulfonimidoyl)butanoic acid

MSX

inhibit,Inhibitor,L Methionine DL sulfoximine,LMethionineDLsulfoximine

MSX (L-Methionine-DL-sulfoximine)

15985-39-4

CH3SONHCH2CH2CHNH2CO2H

Peptide Synthesis

Specialty Synthesis

Methionine

Amino Acid Derivatives

Sulfur & Selenium Compounds

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives