L-Methioninol
- Product Name
- L-Methioninol
- CAS No.
- 2899-37-8
- Chemical Name
- L-Methioninol
- Synonyms
- H-MET-OL;L-Met-ol;H-L-MET-OL;L-Methionionl;L-METHIONINOL;H-METHIONINOL;L-(-)-METHIONINOL;(S)-(-)-METHIONANOL;(S)-(-)-METHIONINOL;L-Methioninol, 99+%
- CBNumber
- CB8148573
- Molecular Formula
- C5H13NOS
- Formula Weight
- 135.23
- MOL File
- 2899-37-8.mol
L-Methioninol Property
- Melting point:
- 31-33 °C
- alpha
- -12.5 º (c=1.4, EtOH)
- Boiling point:
- 120 °C(Press: 3 Torr)
- Density
- 0.984 (estimate)
- refractive index
- n20/D 1.5216(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 12.72±0.10(Predicted)
- form
- Crystalline Low Melting Solid
- color
- White transparent
- optical activity
- [α]21/D 12.7°, c = 1.4 in ethanol
- BRN
- 2231656
- CAS DataBase Reference
- 2899-37-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 860239
- Product name
- (S)-(−)-Methioninol
- Purity
- 98%
- Packaging
- 1G
- Price
- $122
- Updated
- 2023/01/07
- Product number
- M0929
- Product name
- L-(-)-Methioninol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $181
- Updated
- 2025/07/31
- Product number
- M0929
- Product name
- L-(-)-Methioninol
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $41
- Updated
- 2025/07/31
- Product number
- M260558
- Product name
- L-Methioninol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 239346
- Product name
- L-Methioninol
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
L-Methioninol Chemical Properties,Usage,Production
Chemical Properties
white transparent crystalline low melting solid
Uses
L-Methioninol is a methionine derivative that increases bladder excitability by inhibiting stretch-dependent K+ channels.
Synthesis
63-68-3
2899-37-8
The general procedure for the synthesis of (S)-2-amino-4-(methylthio)butan-1-ol from L-methionine is as follows (refer to Examples 1-46): 38 mL (300 mmol) of chlorotrimethylsilane was added slowly and dropwise to 200 mL of an anhydrous tetrahydrofuran suspension containing 3.3 g (150 mmol) of lithium borohydride under ice bath cooling conditions. The reaction mixture was stirred for 30 min and then 7.5 g (50 mmol) of L-methionine was added gradually, followed by continued stirring at room temperature overnight. Upon completion of the reaction, methanol was slowly added under ice bath cooling conditions until hydrogen release ceased. Subsequently, the solvent was removed by distillation under reduced pressure. To the residue, 10% sodium hydroxide solution was added and then extracted twice with chloroform. The chloroform extracted layers were combined, dried with anhydrous sodium sulfate and finally the solvent was removed by distillation under reduced pressure to give 5.12 g (75% yield) of the target product (S)-2-amino-4-(methylthio)butan-1-ol (Compound No. 1-46).
References
[1] European Journal of Organic Chemistry, 2008, # 9, p. 1608 - 1614
[2] Angewandte Chemie, 1989, vol. 101, # 2, p. 220 - 222
[3] European Journal of Organic Chemistry, 2004, # 12, p. 2715 - 2722
[4] Journal of Organic Chemistry, 1990, vol. 55, p. 3749 - 3755
[5] Journal of Organic Chemistry, 2008, vol. 73, # 3, p. 1077 - 1087
L-Methioninol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Methioninol manufacturers
- Product
- L-Methioninol 2899-37-8
- Price
- US $20.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2018-07-30