L-Methionine methyl ester hydrochloride
- Product Name
- L-Methionine methyl ester hydrochloride
- CAS No.
- 2491-18-1
- Chemical Name
- L-Methionine methyl ester hydrochloride
- Synonyms
- (S)-Methyl 2-aMino-4-(Methylthio)butanoate hydrochloride;H-Met-OMeCl;Met-OMe.HCl;H-MET-OME HCL;H-MET-OME·HCL;L-Met-Ome·HCl;H-L-Met-OMe*HCl;H-Met-OMea€￠ HCl;METHIONINE-OME HCL;H-MET-OME HYDROCHLORIDE
- CBNumber
- CB0290878
- Molecular Formula
- C6H14ClNO2S
- Formula Weight
- 199.7
- MOL File
- 2491-18-1.mol
L-Methionine methyl ester hydrochloride Property
- Melting point:
- 151-153 °C(lit.)
- alpha
- 26 º (c=5, H2O 24 ºC)
- refractive index
- 26 ° (C=1, H2O)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- color
- White to beige
- optical activity
- [α]22/D +25.9°, c = 1 in H2O
- Water Solubility
- Soluble in water.
- Sensitive
- Hygroscopic
- BRN
- 3913214
- InChI
- InChI=1/C6H13NO2S.ClH/c1-9-6(8)5(7)3-4-10-2;/h5H,3-4,7H2,1-2H3;1H/t5-;/s3
- InChIKey
- MEVUPUNLVKELNV-USHJBNIQNA-N
- SMILES
- [C@H](N)(CCSC)C(=O)OC.Cl |&1:0,r|
- CAS DataBase Reference
- 2491-18-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 860409
- Product name
- L-Methionine methyl ester hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $247
- Updated
- 2025/07/31
- Product number
- M0853
- Product name
- L-Methionine Methyl Ester Hydrochloride
- Purity
- >96.0%(T)
- Packaging
- 5g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- 283791
- Product name
- L-Methionine methyl ester hydrochloride
- Packaging
- 25g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- M260485
- Product name
- L-Methionine Methyl Ester Hydrochloride
- Packaging
- 25g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 239341
- Product name
- L-Methionine methyl ester hydrochloride
- Packaging
- 5g
- Price
- $156
- Updated
- 2021/12/16
L-Methionine methyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Methionine methyl ester hydrochloride is used as a starting material for the synthesis of a protected glycine derivative, a versatile asymmetric building block.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
63-68-3
2491-18-1
Synthesis Example 1: L-methionine (0.5 g, 1 eq.) was suspended in a 100 mL round-bottomed flask fitted with a magnetic stirrer, methanol (30 mL, concentration 0.1 M) was added and cooled to 0°C under nitrogen atmosphere. Thionyl chloride (0.5 mL, 2 equiv.) was added slowly and dropwise to the above suspension, followed by heating and refluxing the reaction for 16 hours. After completion of the reaction, the solvent was removed by rotary evaporator to give a light yellow solid. The solid was ground with hot ether and the ether solution was removed by filtration to give a white solid L-methionine methyl ester hydrochloride (0.65561 g, 98% yield). The product was further purified by vacuum drying.1H NMR (D2O, 500 MHz) δH: 4.24 (1H, m, CH), 3.79 (3H, s, OCH3), 2.63 (2H, t, CH2), 2.25 (1H, m, CH2), 2.16 (1H, m, CH2), 2.06 (1H, s, SCH3). 13C NMR (D2O, 125 MHz) δC: 170.58 (C=O), 53.64 (OCH3), 51.70 (CH), 28.71 (CH2), 28.41 (CH2), 13.85 (SCH3). IR (neat, vmax, cm-1): 2880.8/2676.2 (CH3, CH2, CH), 2016.2, 1742.2 (C=O, ester), 1483.6, 1443.5, 1227, 1194.7, 1149.8, 1079.5 (C-O). HRMS m/z (+ESI): C6H14NO2S, calculated mass = 164.074 (error = 0.07 ppm).
References
[1] Journal of Organic Chemistry, 2011, vol. 76, # 1, p. 201 - 215
[2] Journal of the American Chemical Society, 2017, vol. 139, # 40, p. 14077 - 14089
[3] Patent: WO2012/131313, 2012, A1. Location in patent: Page/Page column 49
[4] Patent: US2014/39200, 2014, A1. Location in patent: Paragraph 0376-0380
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
L-Methionine methyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
L-Methionine methyl ester hydrochloride Suppliers
- Tel
- 021-34621078 13120882795
- Fax
- 021-34622517
- 465106944@qq.com
- Country
- China
- ProdList
- 857
- Advantage
- 56
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
View Lastest Price from L-Methionine methyl ester hydrochloride manufacturers
- Product
- L-Methionine methyl ester hydrochloride 2491-18-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000
- Release date
- 2024-09-09
- Product
- L-Methionine methyl ester hydrochloride 2491-18-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-26
- Product
- L-Met-OMe.HCl 2491-18-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 100kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-02