1-(4-Fluorobenzyl)-2-chlorobenzimidazole

Product Name: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole
CAS No.: 84946-20-3
Chemical Name: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole
Synonyms: 1-(4-Fluorobenzyl)-2;Mizolastine Impurity 19;1-(4-Fluorobenzyl)-2-Chloro-Be;N-METHYL-N-(-CHLOROETHYL) ANILINE;3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE;2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE;1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL&;1-(4-Flourobenzyl)-2-chlorobenzimidazole;3-(4-Fluorobenzyl)-2-Chlorobenzimidazole;1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE
CBNumber: CB7692741
Molecular Formula: C14H10ClFN2
Formula Weight: 260.69
MOL File: 84946-20-3.mol

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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Property

Melting point:: 83-87 °C(lit.)
Boiling point:: 432.3±47.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 3.42±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C14H10ClFN2/c15-14-17-12-3-1-2-4-13(12)18(14)9-10-5-7-11(16)8-6-10/h1-8H,9H2
InChIKey: PGXALMVNIRPELS-UHFFFAOYSA-N
SMILES: C1(Cl)N(CC2=CC=C(F)C=C2)C2=CC=CC=C2N=1
CAS DataBase Reference: 84946-20-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2850
Product name: 2-Chloro-1-(4-fluorobenzyl)benzimidazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $38
Updated: 2024/03/01

TCI Chemical

Product number: C2850
Product name: 2-Chloro-1-(4-fluorobenzyl)benzimidazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $189
Updated: 2024/03/01

AK Scientific

Product number: I087
Product name: 1-(4-Fluorobenzyl)-2-chloro-benzimidazole
Packaging: 1g
Price: $21.68
Updated: 2021/12/16

AK Scientific

Product number: I087
Product name: 1-(4-Fluorobenzyl)-2-chloro-benzimidazole
Packaging: 5g
Price: $78.64
Updated: 2021/12/16

Matrix Scientific

Product number: 090839
Product name: 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
Purity: 95+%
Packaging: 1g
Price: $95
Updated: 2021/12/16

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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A novel aldose reductase (ALR2) inhibitor.

Synthesis

4857-06-1

459-46-1

84946-20-3

General procedure for the synthesis of 1-(4-fluorobenzyl)-2-chlorobenzimidazole from 2-chlorobenzimidazole and 4-fluorobenzyl bromide: To a solution of 2-chlorobenzimidazole (5 g, 32.7 mmol) in acetonitrile (30 ml) was added potassium hydroxide (2.62 g, 46.6 mmol). The mixture was heated to 80°C and stirred for 30 minutes until the solution was clarified. After cooling to room temperature, 4-fluorobenzyl bromide (9.29 g, 49.1 mmol) was added and the reaction was refluxed at 80 °C for 5 h. The reaction solution appeared white and turbid. After completion of the reaction, the reaction solution was extracted with dichloromethane (100 mL x 3) three times, the organic layers were combined, washed with distilled water and dried with anhydrous magnesium sulfate. After filtration, the organic phase was concentrated to give a white solid. It was recrystallized by acetone/petroleum ether mixed solvent, cooled, filtered and dried to obtain a white solid product in 91.1% yield.

References

[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 245 - 249
[2] Patent: CN104910894, 2017, B. Location in patent: Paragraph 0032; 0034; 0036; 0037; 0055
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6291 - 6294
[4] Heterocycles, 1999, vol. 51, # 11, p. 2561 - 2573
[5] Patent: US5922737, 1999, A

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Suppliers

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View Lastest Price from 1-(4-Fluorobenzyl)-2-chlorobenzimidazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-13

Career Henan Chemical Co

Product: 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-08

84946-20-3, 1-(4-Fluorobenzyl)-2-chlorobenzimidazoleRelated Search:

2-Chlorobenzimidazole Methyl salicylate Benzyl chloride 2-Chloromethylbenzimidazole Methyl acrylate Methanol Methylparaben Kresoxim-methyl Benzyl chloromethyl ether Benzimidazole METSULFURON METHYL Basic Violet 1 Tribenuron methyl Mizolastine Impurity 8 Mizolastine Impurity 3 Acetate Mizolastine Impurity 9 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine Mizolastine Impurity 5

2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole

2-Chloro-1-(4-fluorobenzyl)benzimidazole 97%

N-METHYL-N-(-CHLOROETHYL) ANILINE

3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE

1-(4'-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOLE

1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE

1-(4-FLUOROPHENYLMETHYL)-2-CHLOROBENZIMIDAZOLE

2-CHLORO-1-(4-FLUOROBENZYL)-1H-BENZIMIDAZOLE

2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE

2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole

2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole(CFMB)

1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL&

1-(4-Flourobenzyl)-2-chlorobenzimidazole

1-(4-Fluorobenzyl)-2-Chloro-Be

1-(4-fluorobenzyl)-2-chlorobenzimidazole (intermediate of mizolastine)

1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole

1-(4-fluorobenzyl)-2-chloro-1H-benzo[d]imidazole

1-(4-Fluorobenzyl)-2-chlorobenzimidazole, 2-Chloro-1-(4-fluorobenzyl)-1H-benzimidazole

1-(4-Fluorobenzyl)-2

1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole

3-(4-Fluorobenzyl)-2-Chlorobenzimidazole

2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole

2-Chloro-1-(4-fluorobenzyl)benzimidazole &gt

1H-Benzimidazole, 2-chloro-1-[(4-fluorophenyl)methyl]-

Mizolastine Impurity 19

2-Chloro-1-(4-fluorobenzyl)benzimidazole, ≥ 98.0%

2-Chloro-1-(4-fluorobenzyl)benzimidazole, 10 mM in DMSO

84946-20-3

C14H10ClFN2

Benzimidazoles

Building Blocks

Heterocyclic Building Blocks

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics

Heterocycles

PHARMACEUTICAL INTERMEDIATES

Imidazol&Benzimidazole

(intermediate of mizolastine)