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EA4

Product Name
EA4
CAS No.
389614-94-2
Chemical Name
EA4
Synonyms
EA4;7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione;5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
CBNumber
CB7697201
Molecular Formula
C19H17ClN2O2
Formula Weight
340.8
MOL File
389614-94-2.mol
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EA4 Property

Boiling point:
508.3±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
-196°C
solubility 
≤1mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
crystalline solid
pka
6.14±0.44(Predicted)
color 
Light blue to blue
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CB_96073116
Product name
Ea.4
Purity
96073116
Packaging
96073116-DNA-5UG
Price
$390
Updated
2024/03/01
Sigma-Aldrich
Product number
CB_96073116
Product name
Ea.4
Purity
96073116
Packaging
1VIAL
Price
$951
Updated
2024/03/01
Cayman Chemical
Product number
10111
Product name
EA4
Purity
≥95%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
10111
Product name
EA4
Purity
≥95%
Packaging
10mg
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
10111
Product name
EA4
Purity
≥95%
Packaging
50mg
Price
$710
Updated
2024/03/01
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EA4 Chemical Properties,Usage,Production

Biological Activity

ki: 130 μmea4 is a rpla2 inhibitor.rpla2, a calcium-dependent cytosolic phospholipase a2 (cpla2), was initially isolated and characterized from bovine and human red blood cells. with a molecular mass of 42 kda, cpla2 shows biochemical properties similar to cpla2 type iv.

in vitro

it was found that ea4 was able to inhibit a ca(2+) ionophore-induced arachidonic acid release from both human and bovine red blood cells, demonstrating that this enzyme was responsible for the ca(2+)-dependent arachidonic acid release from mammalian red blood cells [1]. another study found that in mouse hepatoma hepa-1c1c7 cells, ea4 could cause a significant induction of the cyp1a1-mediated ethoxyresorufin o-deethylase activity time- and concentration-dependently, and such induction was accompanied by an increase of the cyp1a1 mrna transcription. morevoer, in human cells including mcf-7 (human breast adenocarcinoma cell line), hepg2 (human hepatocarcinoma), and hl-60 (human promyelocytic cell line), the expression of cyp1a1 mrna could be also induced by ea4 treatment. in addition, cyp1b1 mrna was increased by ea4 in mcf-7 cells [2].

References

1. shin, h.s.,chin, m.r.,kim, j.s., et al. purification and characterization of a cytosolic, 42-kda and ca2+-dependent phospholipase a2 from bovine red blood cells. the journal of biological chemisty 277, 21086-21094 (2002).2. chun, y.j.,lee, b.y.,yang, s.a., et al. induction of cytochrome p450 1a1 gene expression by a vitamin k3 analog in mouse hepatoma hepa-1c1c7 cells. molecules and cells 12, 190-196 (2001).

EA4 Preparation Products And Raw materials

Raw materials

Preparation Products

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EA4 Suppliers

BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

389614-94-2, EA4Related Search:


  • EA4
  • 7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione
  • 5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
  • 389614-94-2