(4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER
- Product Name
- (4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER
- CAS No.
- 20026-96-4
- Chemical Name
- (4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER
- Synonyms
- Ethyl 3-(4-chlorophenyl)propiolate;ethyl 3-(4-chlorophenyl)prop-2-ynoate;(4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER;(4-Chlorophenyl)-2-propynoic acid ethyl ester;3-(4-Chlorophenyl)-2-propynoic acid ethyl ester;2-Propynoic acid, 3-(4-chlorophenyl)-, ethyl ester
- CBNumber
- CB7698228
- Molecular Formula
- C11H9ClO2
- Formula Weight
- 208.64
- MOL File
- 20026-96-4.mol
(4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER Property
- Melting point:
- 43-44 °C
- Boiling point:
- 123-125 °C(Press: 0.25 Torr)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E940503
- Product name
- Ethyl3-(4-Chlorophenyl)propiolate
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- AS47102
- Product name
- Ethyl 3-(4-chlorophenyl)propiolate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- HCH0133700
- Product name
- (4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.46
- Updated
- 2021/12/16
- Product number
- AS47102
- Product name
- Ethyl 3-(4-chlorophenyl)propiolate
- Purity
- 95+%
- Packaging
- 5G
- Price
- $992
- Updated
- 2021/12/16
- Product number
- A125204
- Product name
- Ethyl3-(4-chlorophenyl)propiolate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
(4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
637-87-6
623-47-2
20026-96-4
a) Synthesis of ethyl (4-chlorophenyl)-propynoate (Va): Under argon protection, a dry four-necked flask containing 1-chloro-4-iodobenzene (130.0 g, 0.55 mol), bis(triphenylphosphine)palladium(II) chloride (7.57 g, 10.8 mmol, 2 mol%), and cuprous(I) iodide (4.19 g, 22.0 mmol, 4 mol%) was added to a dry four-necked flask was added with anhydrous THF (1.4 L). Cesium carbonate (355.3 g, 1.09 mol, 2 equiv) was added slowly over 5 min at room temperature. Subsequently, ethyl propargylate (111.3 mL, 1.09 mol, 2 eq.) was added and the reaction mixture was stirred at 35 °C overnight. Upon completion of the reaction, ethyl propiolate (11.1 mL, 0.11 mol, 0.2 eq.) was added retrospectively and stirring was continued at 35 °C for 3 hours. The reaction mixture was concentrated to dryness by rotary evaporation and the residue was dissolved in toluene (0.5 L) and heptane (1 L). The resulting suspension was stirred at 40 °C for 1 h and then filtered through diatomaceous earth. The filtrate was concentrated and purified by silica gel column chromatography (eluent: toluene/heptane, 1:2, v/v) to give the light yellow solid product Va (72.6 g, 61% yield).
References
[1] Patent: US2010/152462, 2010, A1. Location in patent: Page/Page column 4
[2] Patent: US2011/144081, 2011, A1. Location in patent: Page/Page column 45-46
[3] Patent: WO2011/85886, 2011, A1. Location in patent: Page/Page column 91-92
[4] Organic Letters, 2013, vol. 15, # 18, p. 4888 - 4891
[5] Organic Letters, 2014, vol. 16, # 10, p. 2606 - 2609
(4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER manufacturers
- Product
- (4-CHLORO-PHENYL)-PROPYNOIC ACID ETHYL ESTER 20026-96-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12