4-Chlorophenylacetylene

Product Name: 4-Chlorophenylacetylene
CAS No.: 873-73-4
Chemical Name: 4-Chlorophenylacetylene
Synonyms: 1-CHLORO-4-ETHYNYLBENZENE;oro-4-ethynyL;(4-Chlorophenyl)ethyne;4-CHOROPHENYLACETYLENE;p-Ethynylchlorobenzene;4-CHLOROPHENYLACETYLENE;4-Chlorophenylcaetylene;1-(4-Chlorophenyl)ethyne;(p-Chlorophenyl)acetylene;4-Ethynyl-1-chlorobenzene
CBNumber: CB4129718
Molecular Formula: C8H5Cl
Formula Weight: 136.58
MOL File: 873-73-4.mol

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4-Chlorophenylacetylene Property

Melting point:: 45-47 °C(lit.)
Boiling point:: 79-82 °C (23 mmHg)
Density: 1.24 g/cm3(Temp: 50 °C)
Flash point:: 10 °C
storage temp.: Sealed in dry,2-8°C
solubility: Acetone, Chloroform (Slightly), Dichloromethane, DMF, DMSO, Ethanol, Ethyl Acetate)
form: Crystalline Mass
color: Yellow to pale brown
Water Solubility: Insoluble in water. Soluble in acetone, chloroform, dichloromethane, DMF, DMSO, ethanol, ethyl acetate, hexane, methanol,THF and toluene.
Stability:: Light Sensitive
InChI: InChI=1S/C8H5Cl/c1-2-7-3-5-8(9)6-4-7/h1,3-6H
InChIKey: LFZJRTMTKGYJRS-UHFFFAOYSA-N
SMILES: C1(Cl)=CC=C(C#C)C=C1
CAS DataBase Reference: 873-73-4(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-chloro-4-ethynyl-(873-73-4)

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Safety

Hazard Codes: F,Xi
Risk Statements: 36/37/38-11
Safety Statements: 16-26-36-37/39
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: FLAMMABLE
HazardClass: 4.1
PackingGroup: Ⅱ
HS Code: 29039990
Storage Class: 4.1B - Flammable solid hazardous materials
Hazard Classifications: Eye Irrit. 2
Flam. Sol. 1
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 206474
Product name: 1-Chloro-4-ethynylbenzene
Purity: 98%
Packaging: 1g
Price: $37.5
Updated: 2025/07/31

TCI Chemical

Product number: C2670
Product name: 1-Chloro-4-ethynylbenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $75
Updated: 2025/07/31

TCI Chemical

Product number: C2670
Product name: 1-Chloro-4-ethynylbenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $226
Updated: 2025/07/31

Usbiological

Product number: C5029-38F
Product name: 4-Chlorophenylacetylene
Packaging: 1g
Price: $368
Updated: 2021/12/16

TRC

Product number: C376500
Product name: 4-Chlorophenylacetylene
Packaging: 10g
Price: $260
Updated: 2021/12/16

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4-Chlorophenylacetylene Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

4-Chlorophenylacetylene is used as pharmaceutical intermediate.

Synthesis Reference(s)

Synthesis, p. 728, 1984 DOI: 10.1055/s-1984-30947

General Description

1-Chloro-4-ethynylbenzene undergoes standard Sonogashira reaction with iodophenyl groups on the film surfaces via the formation of C?C bonds.

Synthesis

9.5 g (0.04 mol) of 4-chloroiodobenzene and 4.2 g (0.05 mol) of 3-methylbutynol, 0.3 g of diphenylphosphine palladium dichloride Pd[(C6H5)3P]2Cl2, and 100 ml of triethylamine were mixed, and the mixture was allowed to mix and stir under the protection of nitrogen for 15 minutes. While keeping the mixture in nitrogen atmosphere, 180 mg of cuprous iodide was added. A precipitate was observed to form almost immediately. The mixture was stirred at room temperature for about 12 h. The mixture was diluted by adding ether (200 ml) and filtered. The resulting filtrate was removed from the filtrate by evaporation under reduced pressure to remove almost all the solvent and the residue was diluted with 150 ml of toluene. To the resulting solution 2.5 g of NaOH powder was added and heated to reflux the reaction for 4 hours. After filtration while hot, the solvent was removed from the filtrate by evaporation under reduced pressure. 4.6 g of 4-chlorophenylacetylene in the form of a waxy solid was obtained.

4-Chlorophenylacetylene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chlorophenylacetylene Suppliers

Americas 1 Belgium 3 Canada 2 CHINA 176 Europe 2 France 1 Germany 7 India 9 Japan 2 Lithuania 1 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 43 Global 261

Shanghai Union Medical Technology Co. Ltd.

Tel: 13120563767
Fax: 15669989863
Email: chemchen925@outlook.com
Country: China
ProdList: 986
Advantage: 58

Zhengzhou HQ Material Co., Ltd.

Tel: 0371-67759225 13526468238
Email: sales@hqmat.com
Country: China
ProdList: 588
Advantage: 58

Shanghai Jinyuanrui Pharmaceutical Technology Co., Ltd

Tel: 021-18217523 18217523428
Email: jinrui750315@126.com
Country: China
ProdList: 337
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9401
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

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View Lastest Price from 4-Chlorophenylacetylene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Chlorophenylacetylene 873-73-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-10

Shanghai UCHEM Inc.

Product: 4-Chlorophenylcaetylene 873-73-4
Price: US $24.00-227.00/g
Min. Order: 5g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-08

Henan Fengda Chemical Co., Ltd

Product: 4-Chlorophenylacetylene 873-73-4
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

873-73-4, 4-ChlorophenylacetyleneRelated Search:

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873-73-4

C8H5Cl

ClC6H4CCH

C8H6Cl

Halogenated Hydrocarbons

Organic Building Blocks

Alkynyl

Building Blocks

Alkynyl

Building Blocks

Chemical Synthesis

Halogenated Hydrocarbons

Organic Building Blocks

Aromatics Compounds

Aromatics

pharmacetical

Pyridines