4-(2-Aminoethyl)-1-Boc-piperidine
- Product Name
- 4-(2-Aminoethyl)-1-Boc-piperidine
- CAS No.
- 146093-46-1
- Chemical Name
- 4-(2-Aminoethyl)-1-Boc-piperidine
- Synonyms
- tert-butyl 4-(2-aminoethyl)piperidine-1-carboxylate;4-(AMINOETHYL)-1-BOC-PIPERIDINE;1-N-Boc-4-(Aminoethyl)-piperidine;4-(2-AMINOETHYL)-1-BOC-PIPERIDINE;4-(AMINOETHYL)-1-N-BOC-PIPERIDINE;4-(2-Aminoethyl)-1-N-Boc-piperidine;4-(Aminoethyl)-1-N-Boc-piperidine Hcl;4-(Aminoethyl)-1-N-Boc-piperidine;4-(2-Aminoethyl)piperidine, N1-BOC protected;4-(Aminoethyl)-1-N-Boc-piperidine - [A13695]
- CBNumber
- CB7698541
- Molecular Formula
- C12H24N2O2
- Formula Weight
- 228.33
- MOL File
- 146093-46-1.mol
4-(2-Aminoethyl)-1-Boc-piperidine Property
- Boiling point:
- 316.0±15.0 °C(Predicted)
- Density
- 1.010±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- semisolid
- pka
- 10.43±0.10(Predicted)
- color
- off-white to light yellow
- InChI
- InChI=1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9,13H2,1-3H3
- InChIKey
- LBQDLHPFISVBRU-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(CCN)CC1
- CAS DataBase Reference
- 146093-46-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN2811
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A608030
- Product name
- 4-(2-Aminoethyl)-1-boc-piperidine
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FB139873
- Product name
- tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A13695
- Product name
- 4-(Aminoethyl)-1-N-Boc-piperidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB139873
- Product name
- tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- W3189
- Product name
- tert-Butyl4-(2-aminoethyl)piperidine-1-carboxylate
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
4-(2-Aminoethyl)-1-Boc-piperidine Chemical Properties,Usage,Production
Synthesis
256411-39-9
146093-46-1
General procedure for the synthesis of 2-(N-Boc-4-piperidinyl)ethylamine from 1-Boc-4-(cyanomethyl)piperidine: tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (20 g, 89.29 mmol) and NH4OH (9 mL) were dissolved in methanol (200 mL) and Raney Ni (6 g, 101.69 mmol) was added. The reaction was carried out at 50°C for 5 h under H2 pressure of 50 psi. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated to afford the target product 2-(N-Boc-4-piperidinyl)ethylamine (20.5 g, 100%) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 1.06-1.19 (m, 2H), 1.44 (d, J = 7.41 Hz, 2H), 1.47 (s 9H), 1.50-1.58 (m, 1H), 1.66 (d, J = 12.49 Hz, 2H), 2.09 (br.s., 2H), 2.70 (t, J = 12.29 Hz, 2H), 2.75-2.83 (m, 2H), 4.08 (br.s., 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4805 - 4811
4-(2-Aminoethyl)-1-Boc-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(2-Aminoethyl)-1-Boc-piperidine manufacturers
- Product
- 4-(2-Aminoethyl)-1-Boc-piperidine 146093-46-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25